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| | OPIPRAMOL DIHYDROCHLORIDE Basic information |
| Product Name: | OPIPRAMOL DIHYDROCHLORIDE | | Synonyms: | 4-(3-(5h-dibenz(b,f)azepin-5-yl)propyl)-1-piperazineethanodihydrochloride;4-(3-(5h-dibenzo(b,f)azepina-5-il)propil)-1-(2-idrossietil)piperazinadiclori;5-(gamma-(beta-hydroxyethylpiperazino)propyl)-5h-dibenzo(b,f)azepinedihydroc;ensidon;insidondihydrochloride;opipramolhydrochloride;4-[3-(5H-dibenz(b,f)azepin-5-yl)propyl]piperazine-1-ethanol dihydrochloride;Opipramol dihydrochloride >=98% (HPLC), solid | | CAS: | 909-39-7 | | MF: | C23H31Cl2N3O | | MW: | 436.41774 | | EINECS: | 213-000-2 | | Product Categories: | Dopamine receptor | | Mol File: | 909-39-7.mol |  |
| | OPIPRAMOL DIHYDROCHLORIDE Chemical Properties |
| Melting point | 210° (FR M209); mp 228-230° (DE 1133729) | | solubility | H2O: ~24 mg/mL | | form | solid | | color | yellow | | Water Solubility | H2O: ~24mg/mL | | InChI | 1S/C23H29N3O.2ClH/c27-19-18-25-16-14-24(15-17-25)12-5-13-26-22-8-3-1-6-20(22)10-11-21-7-2-4-9-23(21)26;;/h1-4,6-11,27H,5,12-19H2;2*1H | | InChIKey | DLTOEESOSYKJBK-UHFFFAOYSA-N | | SMILES | Cl[H].Cl[H].OCCN1CCN(CCCN2c3ccccc3C=Cc4ccccc24)CC1 |
| Hazard Codes | Xn,N | | Risk Statements | 22-50/53 | | Safety Statements | 60-61 | | RIDADR | UN 3077 9 / PGIII | | WGK Germany | 3 | | RTECS | TL9100000 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Aquatic Acute 1
Aquatic Chronic 1 |
| | OPIPRAMOL DIHYDROCHLORIDE Usage And Synthesis |
| Originator | Insidon,Geigy,W. Germany,1962 | | Uses | antidepressant, antipsychotic;'sigma antagonist | | Manufacturing Process | A solution of 5-(3-toluene-p-sulfonyloxypropyl)dibenzazepine (9.2g) and 1-(2hydroxyethyl)piperazine (8.6g) in anhydrous toluene (50 cc) is heated at boiling point under reflux for 4 hours.
After cooling, distilled water (75 cc) is added. The aqueous phase is decanted. The toluene solution is washed with distilled water (25 cc) and then extracted with N hydrohloric acid (40 cc). The hydrochloric acid solution is made alkaline to phenolphthalein with sodium hydroxide (d = 1.33).The base which separates is extracted with chloroform (50 cc). The chloroform solution is dried over anhydrous sodium sulfate and then evaporated to dryness. There are obtained 5-[3-(4-β-hydroxyethylpiperazino)propyl]dibenzazepine (7.95g), the dihydrochloride of which, crystallized from ethanol, melts at about 210°C. | | Therapeutic Function | Antidepressant, Antipsychotic | | Biological Activity | δ1/δ2 opioid receptor agonist; an antagonist at D2, 5HT2 and H1 receptors; atypical antidepressant, antipsychotic and anxiolytic |
| | OPIPRAMOL DIHYDROCHLORIDE Preparation Products And Raw materials |
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