2-Amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide

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2-Amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide Basic information
Product Name:2-Amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
Synonyms:NSC727447;2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiophene-3-carboxamide;2-Amino-4H,5H,6H,7H,8H-cyclohepta[b]thiophene-3-carboxamide;2-Amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-3-carboxamide
CAS:40106-12-5
MF:C10H14N2OS
MW:210.3
EINECS:
Product Categories:
Mol File:40106-12-5.mol
2-Amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide Structure
2-Amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide Chemical Properties
Melting point 154-156 °C(Solv: ethanol (64-17-5))
Boiling point 347.5±42.0 °C(Predicted)
density 1.278±0.06 g/cm3(Predicted)
storage temp. room temp
solubility DMSO: >10mg/mL
form Solid
pka15.70±0.20(Predicted)
color Light brown to brown
InChI1S/C10H14N2OS/c11-9(13)8-6-4-2-1-3-5-7(6)14-10(8)12/h1-5,12H2,(H2,11,13)
InChIKeyLULYZYNTDPUEKK-UHFFFAOYSA-N
SMILESNC(=O)c1c(N)sc2CCCCCc12
Safety Information
Hazard Codes Xn
Risk Statements 22
WGK Germany 3
HazardClass IRRITANT
Storage Class11 - Combustible Solids
Hazard ClassificationsAcute Tox. 4 Oral
MSDS Information
2-Amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide Usage And Synthesis
UsesNSC727447 is an inhibitor of ribonuclease H (Rnase H) of HIV-1 and HIV-2. NSC727447 has little activity against E. coli RNase H, but great selectivity over human Rnase H, with IC50s value of 2.0 μM, 2.5 μM, 100 μM, 10.6 μM, respectively[1].
Biological ActivityNSC727447 is an inhibitor of ribonuclease H (Rnase H) of HIV-1 and HIV-2. NSC727447 has little activity against E. coli RNase H, but gre at selectivity over human Rnase H.
References[1] Michaela Wendeler, et al. Vinylogous Ureas as a Novel Class of Inhibitors of Reverse Transcriptase-Associated Ribonuclease H Activity. ACS Chem Biol. 2008 Oct 17;3(10):635-44. DOI:10.1021/cb8001039
2-Amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide Preparation Products And Raw materials
Raw materials2-Amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carbonitrile-->Cycloheptanone-->2-Cyanoacetamide
Preparation Products3,5,6,7,8,9-hexahydro-4H-cyclohepta[4,5]thieno[2,3-d]pyrimidin-4-one
Tag:2-Amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide(40106-12-5) Related Product Information
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