Norhyodeoxycholic Acid manufacturers
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| | Norhyodeoxycholic Acid Basic information |
| Product Name: | Norhyodeoxycholic Acid | | Synonyms: | Norhyodeoxycholic Acid;24-Norcholan-23-oic acid, 3,6-dihydroxy-, (3α,5β,6α)-;(5β)-3α,6α-dihydroxy-24-norcholan-23-oic acid | | CAS: | 77518-23-1 | | MF: | C23H38O4 | | MW: | 378.55 | | EINECS: | | | Product Categories: | | | Mol File: | 77518-23-1.mol |  |
| | Norhyodeoxycholic Acid Chemical Properties |
| Melting point | 197-198 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3)) | | Boiling point | 536.7±25.0 °C(Predicted) | | density | 1.142±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 30mg/mL; DMF:PBS (pH 7.2) (1:1): 0.5mg/mL; DMSO: 20mg/mL; Ethanol: 20mg/mL | | form | A crystalline solid | | pka | 4.71±0.10(Predicted) |
| | Norhyodeoxycholic Acid Usage And Synthesis |
| Description | Norhyodeoxycholic acid (NHDCA) is a synthetic bile acid and a derivative of hyodeoxycholic acid (HDCA; ).1,2 NHDCA is an intermediate in the synthesis of 3β-sulfooxy-7β-hydroxy-24-nor-5-cholen-23-oic acid, which has been used as an internal standard for the quantification of Δ5-bile acid conjugates that have been identified in patients with Niemann-Pick disease type C1.3 | | Definition | ChEBI: Norhyodeoxycholic acid is a cholanoid. | | References | 1. Schteingart, C.D., and Hofmann, A.F. Synthesis of 24-nor-5β-cholan-23-oic acid derivatives: A convenient and efficient one-carbon degradation of the side chain of natural bile acids J. Lipid Res. 29(10),1387-1395(1988).
2. Une, M., and Hoshita, T. Natural occurrence and chemical synthesis of bile alcohols, higher bile acids, and short side chain bile acids Hiroshima J. Med. Sci. 43(2),37-67(1994).
3. Kakiyama, G., Muto, A., Shimada, M., et al. Chemical synthesis of 3β-sulfooxy-7β-hydroxy-24-nor-5-cholenoic acid: An internal standard for mass spectrometric analysis of the abnormal Δ5-bile acids occurring in Niemann-Pick disease Steroids 74(9),766-772(2009). |
| | Norhyodeoxycholic Acid Preparation Products And Raw materials |
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