- Climbazole
-
-
2026-09-20
- CAS:38083-17-9
- Min. Order: 1kg
- Purity: 99%min
- Supply Ability: 20tons
- Climbazole
-
-
2026-09-20
- CAS:38083-17-9
- Min. Order: 1KG
- Purity: ≥99.5%
- Supply Ability: 200mt/year
- Climbazole
-
- $999.00
-
2026-09-20
- CAS:38083-17-9
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 5000
|
| | Climbazole Chemical Properties |
| Melting point | 96-100°C | | Boiling point | 447.5±40.0 °C(Predicted) | | density | 1.17±0.1 g/cm3(Predicted) | | vapor pressure | 0.001Pa at 25℃ | | refractive index | 1.54 | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Insoluble in water | | form | Solid | | pka | 5.66±0.22(Predicted) | | color | White to Almost white | | Water Solubility | 58mg/L at 25℃ | | BRN | 618020 | | Major Application | agriculture
environmental | | Cosmetics Ingredients Functions | ANTIMICROBIAL
PRESERVATIVE
ANTI-SEBORRHEIC | | InChI | 1S/C15H17ClN2O2/c1-15(2,3)13(19)14(18-9-8-17-10-18)20-12-6-4-11(16)5-7-12/h4-10,14H,1-3H3 | | InChIKey | OWEGWHBOCFMBLP-UHFFFAOYSA-N | | SMILES | CC(C)(C)C(=O)C(Oc1ccc(Cl)cc1)n2ccnc2 | | LogP | 3.83 at 25℃ | | CAS DataBase Reference | 38083-17-9(CAS DataBase Reference) |
| Hazard Codes | Xn,N | | Risk Statements | 22-50/53 | | Safety Statements | 60-61 | | RIDADR | UN 3077 | | WGK Germany | 3 | | RTECS | EL7085000 | | HS Code | 29332900 | | Storage Class | 13 - Non Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Aquatic Acute 1
Aquatic Chronic 1 |
| | Climbazole Usage And Synthesis |
| Risks to the environment | Climbazole (CBZ) is an emerging recalcitrant contaminant in wastewater, which has severe toxic effects on aquatic organisms. | | Description | (±)-Climbazole is an imidazole antifungal agent. It inhibits the growth of C. albicans (MIC = 0.29 μg/ml), as well as clinical isolates of M. pachydermatis (MICs = <0.06-1 μg/ml) and M. furfur (MICs = <0.06-0.5 μg/ml) in vitro. It also reduces the size of Malassezia populations on the skin of naturally infected dogs when used at a dose of 2% in shampoo. (±)-Climbazole (80 mg/kg) increases the levels of cytochrome P450 in rat liver. Formulations containing climbazole have been used in the treatment of dandruff. | | Chemical Properties | White Solid | | Uses | Climbazole is an imidazole antifungal agent that can provide anti-dandruff benefits when incorporated into a shampoo matrix.
s assay and did not induce micronuclei in human lymphocytes. | | Definition | ChEBI: 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one is a ketone that is butan-2-one substituted by a 4-chlorophenoxy and a 1H-imidazol-1-yl group at position 1 and 2 methyl groups at position 3. It is a member of monochlorobenzenes, a member of imidazoles, an aromatic ether, a ketone and a hemiaminal ether. | | Production Methods | Climbazole is commercially produced by reacting chloroether ketone with imidazole in toluene under controlled temperature and acid-binding conditions, followed by crystallisation and purification to yield a high-purity antifungal agent. | | Hazard | Moderately toxic by ingestion. Low toxicity by skin contact. | | Flammability and Explosibility | Non flammable | | Mechanism of action | Systemic with protective and curative action. Sterol demethylation inhibitor. | | Side effects | May cause localized irritation of the skin with symptoms including redness, rashes and itching. | | References | [1] P. CAVANA . Efficacy of a 2% climbazole shampoo for reducing Malassezia population sizes on the skin of naturally infected dogs[J]. Journal de mycologie medicale, 2015, 25 4: Pages 268-273. DOI: 10.1016/j.mycmed.2015.10.004
[2] MARIOS STYLIANOU. Antifungal application of nonantifungal drugs.[J]. Antimicrobial Agents and Chemotherapy, 2014, 58 2: 1055-1062. DOI: 10.1128/aac.01087-13
[3] SCHMIDT D A. In vitro Activity of Climbazole, Clotrimazole and Silver-sulphadiazine against Isolates of Malassezia pachydermatis[J]. Zoonoses and Public Health, 2010, 44 1-10: 193-197. DOI: 10.1111/j.1439-0450.1997.tb00964.x
[4] A SCHMIDT B R H. In vitro susceptibility of Malassezia furfur against azole compounds.[J]. Mycoses, 1996, 39 7-8: 309-312. DOI: 10.1111/j.1439-0507.1996.tb00145.x
[5] KOBAYASHI Y, SUZUKI M, OHSHIRO N, et al. Climbazole is a new potent inducer of rat hepatic cytochrome P450.[J]. The Journal of toxicological sciences, 2001, 62 1: 0. DOI: 10.2131/jts.26.141 | | Pesticide Type | Fungicide |
| | Climbazole Preparation Products And Raw materials |
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