7-Bromobenz[A]Anthracene manufacturers
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| | 7-Bromobenz[A]Anthracene Basic information |
| Product Name: | 7-Bromobenz[A]Anthracene | | Synonyms: | 10-brom-1,2-benzanthracen;10-bromo-1,2-benzanthracene;7-bromo-benz(a)anthracen;7-bromobenzanthracene;7-BROMO-BENZ[A]ANTHRACENE 98+%;7-BROMOBENZ[A]ANTHRACENE;Bromobenzanthracene;AR-E 4 7-BROMOBENZ(A)ANTHRACENE | | CAS: | 32795-84-9 | | MF: | C18H11Br | | MW: | 307.18 | | EINECS: | | | Product Categories: | | | Mol File: | 32795-84-9.mol | ![7-Bromobenz[A]Anthracene Structure](CAS/GIF/32795-84-9.gif) |
| | 7-Bromobenz[A]Anthracene Chemical Properties |
| Melting point | 152 °C | | Boiling point | 361.79°C (rough estimate) | | density | 1.3995 (rough estimate) | | refractive index | 1.6000 (estimate) | | storage temp. | Room Temperature, under inert atmosphere | | solubility | Chloroform (Slightly), Dichloromethane (Slightly) | | form | Solid | | color | Light Beige to Dark Yellow | | InChI | InChI=1S/C18H11Br/c19-18-15-8-4-2-6-13(15)11-17-14-7-3-1-5-12(14)9-10-16(17)18/h1-11H | | InChIKey | LGRNWCDRODWMOH-UHFFFAOYSA-N | | SMILES | C12=CC=CC=C1C=CC1C2=CC2C(=CC=CC=2)C=1Br |
| RTECS | CW0180000 | | HS Code | 2903.99.8001 |
| | 7-Bromobenz[A]Anthracene Usage And Synthesis |
| Uses | 7-Bromobenzo[A]anthracene is an organic synthesis intermediate, particularly used in the pharmaceutical and fine chemical industries to construct complex aromatic compounds. | | Toxicity evaluation |
The tumorigenicity of 7-chlorobenz[α]anthracene (7-C1-BA), an environmental contaminant, and 7-bromobenz[α]anthracene (7-Br-BA) was determined in the male B6C3F1 newborn mouse. Mice receiving 7-C1-BA and 7-Br-BA by i.p. injections at a dose of 1600 nmol per mouse on 1, 8, and 15 days after birth developed 92 and 96% hepatocellular adenomas, and 100 and 83% hepatocellular carcinoma, respectively. Metabolism by liver microsomes of 15-day-old mice each produced the corresponding trans-3,4-dihydrodiol. Analysis by 32P-postlabeling/HPLC indicated the presence of DNA adducts derived from 7-C1-BA trans-3,4-dihydrodiol and 7-Br-BA trans-3,4-dihydrodiol. The results indicate that both 7-C1-BA and 7-Br-BA are potent carcinogens and that bay-region diol epoxides are the ultimate metabolites that lead to DNA adduct formation and tumor initiation[1].
| | References | [1] Peter P. Fu. “Potent tumorigenicity of 7-chlorobenz[α]anthracene and 7-bromobenz[α]anthracene in the neonatal B6C3F1 male mouse.” Cancer letters 101 1 (1996): Pages 37-42.
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| | 7-Bromobenz[A]Anthracene Preparation Products And Raw materials |
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