- 2-Aib-Ome.Hcl
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2026-08-18
- CAS:15028-41-8
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1T+
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| | ALPHA-AMINOISOBUTYRIC ACID METHYL ESTER HYDROCHLORIDE Basic information |
| | ALPHA-AMINOISOBUTYRIC ACID METHYL ESTER HYDROCHLORIDE Chemical Properties |
| Melting point | 185°C | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | solubility | DMSO (Sparingly), Methanol (Slightly), Water (Slightly) | | form | Crystalline Powder | | color | White | | Water Solubility | Slightly soluble in water. | | InChI | InChI=1S/C5H11NO2.ClH/c1-5(2,6)4(7)8-3;/h6H2,1-3H3;1H | | InChIKey | NVWZNEDLYYLQJC-UHFFFAOYSA-N | | SMILES | C(N)(C)(C)C(=O)OC.Cl | | CAS DataBase Reference | 15028-41-8(CAS DataBase Reference) |
| Safety Statements | 24/25 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29224999 |
| | ALPHA-AMINOISOBUTYRIC ACID METHYL ESTER HYDROCHLORIDE Usage And Synthesis |
| Chemical Properties | White solid | | Uses | Methyl α-aminoisobutyrate is used as a specific substrate of amino acid transport system and in studies on amino acid transport systems. | | Synthesis | 1. 2-Amino-2-methylpropionic acid (10 g, 96.9 mmol) and methanol (330 ml) were added to a reaction vial.
2. The reaction vial was placed in an ice bath and thionyl chloride (17.68 ml, 242.25 mmol) was slowly added dropwise.
3. After the dropwise addition was completed, the ice bath was removed and the reaction mixture was stirred at room temperature for 3 hours.
4. After completion of the reaction, the solvent was removed by vacuum distillation.
5. The residue was dried in an oven at 60 °C to give methyl 2-amino-2-methylpropionate hydrochloride as a white solid (14.59 g, 94.9 mmol, 98% yield). 6. The product was analyzed by 1H NMR.
6. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 8.75 (br, 3H), 3.75 (s, 3H), 1.45 (s, 6H). | | References | [1] Organic Letters, 2012, vol. 14, # 18, p. 4798 - 4801
[2] European Journal of Organic Chemistry, 2004, # 20, p. 4167 - 4176
[3] Patent: WO2013/19091, 2013, A2. Location in patent: Paragraph 936-938
[4] Patent: US2014/206875, 2014, A1. Location in patent: Paragraph 0513-0514; 0568-0569; 0599-0600; 0658-0660
[5] Tetrahedron, 1982, vol. 38, # 14, p. 2165 - 2182 |
| | ALPHA-AMINOISOBUTYRIC ACID METHYL ESTER HYDROCHLORIDE Preparation Products And Raw materials |
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