CORAZONIN manufacturers
- CORAZONIN
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- $1.00
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2020-03-06
- CAS:122929-08-2
- Min. Order: 1g
- Purity: ≥98%
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| Product Name: | CORAZONIN | | Synonyms: | Corazonin, ≥97% (HPLC);Corazonin Pyr-Thr-Phe-Gln-Tyr-Ser-Arg-Gly-Trp-Thr-Asn-NH2;CORAZONIN;CORAZONIN, AMERICAN COCKROACH, PERIPLANETA AMERICANA;CORAZONIN (PERIPLANETA AMERICANA);GLP-THR-PHE-GLN-TYR-SER-ARG-GLY-TRP-THR-ASN-NH2;PYR-TFQYSRGWTN-NH2;PYR-THR-PHE-GLN-TYR-SER-ARG-GLY-TRP-THR-ASN-NH2 | | CAS: | 122929-08-2 | | MF: | C62H84N18O18 | | MW: | 1369.44 | | EINECS: | | | Product Categories: | Peptide | | Mol File: | 122929-08-2.mol |  |
| | CORAZONIN Chemical Properties |
| density | 1.56±0.1 g/cm3(Predicted) | | storage temp. | −20°C | | pka | 9.82±0.15(Predicted) |
| | CORAZONIN Usage And Synthesis |
| Description | A highly conserved neuropeptide produced by the central nervous system in insects, crustaceans, and ticks, CRZ has been implicated in controlling different species- and stage-specific functions. | | Structure | Corazonin is a very conserved N-terminally blocked undecapeptide amidated at the C-terminus. The aa sequence is conserved in all examined arthropods (insects, crustaceans, and ticks). Corazonin is distantly related to the vertebrate gonadotropinreleasing hormone (GnRH) and the GnRH-like peptide from mollusks. | | Properties | Corazonin:Mr 1350–1370; soluble in water, physiological saline, and 50%–70% methanol or ethanol. | | Regulation of synthesis and release | Corazonin expression appears to be constitutive. In locusts, external environmental conditions such as high population density and low temperature seem to elicit corazonin secretion from the CC.In D. melanogaster, corazonin is centrally released from the abdominal interneurons during mating. | | Discovery | Corazonin was isolated as a cardioactive peptide from the corpora cardiaca (CC) of the cockroach Periplaneta americana, and subsequently identified in many arthropods. This neuropeptide controls cuticle melanization in locusts and crayfish, initiation of the ecdysis sequence in moths, and modulation of stress responses and male reproduction in flies. | | Biological functions | Corazonin stimulates the heartbeat in P. americana and Rhodnius prolixus in vitro, but is inactive in vivo and in other insects.Corazonin controls eye pigment migration, melanization of the cuticle, and a shift to the gregarious phase in locusts.In the crustacean Procambarus clarkii, it regulates chromatophore migration in the integument. | | Uses | Corazonin is a highly conserved neuropeptide hormone of wide-spread occurrence in insects, serves a central regulator of caste identity and behavior in social insects. Corazonin is also preferentially expressed in workers and/or foragers from other social insect species[1][2]. | | in vivo | Corazonin (5.4 ng/brain; injection; single dose) suppresses expression of vitellogenin in the brain and stimulates worker-like hunting behaviors, while inhibiting gamergate behaviors, such as dueling and egg deposition in transitioning Harpegnathos individuals[2].
| | References | [1] Kim YJ, et al. Corazonin receptor signaling in ecdysis initiation. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6704-9. DOI:10.1073/pnas.0305291101
[2] Gospocic J, et al. The Neuropeptide Corazonin Controls Social Behavior and Caste Identity in Ants. Cell. 2017 Aug 10;170(4):748-759.e12. DOI:10.1016/j.cell.2017.07.014 |
| | CORAZONIN Preparation Products And Raw materials |
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