- Apramycin sulfate
-
- $47.00
-
2026-07-17
- CAS:65710-07-8
- Purity: 99.86%
- Supply Ability: 10g
- Apramycin sulfate
-
- $47.00
-
2026-07-17
- CAS:65710-07-8
- Purity: 99.86%
- Supply Ability: 10g
- Apramycin sulfate
-
-
2025-06-27
- CAS:65710-07-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 500000kg
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| | Apramycin sulfate Basic information |
| Product Name: | Apramycin sulfate | | Synonyms: | APRAMYCIN SULPHATE;APRAMYCIN SULFATE SALT;5-AMINO-2-[[9-AMINO-8-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXOXY)-5-HYDROXY-4-METHYLAMINO-2,7-DIOXABICYCLO[4.4.0]DEC-3-YL]OXY]-6-(HYDROXYMETHYL)OXANE-3,4-DIOL;NEBRAMYCIN II SULFATE;ApraMycin sulf;Apramycin sulfate solution,1000ppm;D-Streptamine, O-4-amino-4-deoxy-α-D-glucopyranosyl-(1→8)-O-(8R)-2-amino-2,3,7-trideoxy-7-(methylamino)-D-glycero-α-D-allo-octodialdo-1,5:8,4-dipyranosyl-(1→4)-2-deoxy-, sulfate (1:);Apramycin sulfate Solution Solution, 100ppm | | CAS: | 65710-07-8 | | MF: | C21H43N5O15S | | MW: | 637.66 | | EINECS: | 265-890-7 | | Product Categories: | SOLODYN;antibiotic;Amines;Intermediates & Fine Chemicals;Oligosaccharides;Pharmaceuticals;Active Pharmaceutical Ingredients;Peptide Synthesis/Antibiotics;Inhibitors | | Mol File: | 65710-07-8.mol |  |
| | Apramycin sulfate Chemical Properties |
| Melting point | >168°C (dec.) | | Boiling point | 823℃ | | density | 1.56 | | Fp | 451.6°(845°F) | | storage temp. | Inert atmosphere,2-8°C | | solubility | H2O: soluble25mg/mL | | form | powder | | color | white to light yellow | | Water Solubility | Soluble in water. | | JECFA Number | 75 | | InChIKey | WGLYHYWDYPSNPF-RQFIXDHTSA-N | | SMILES | OS(O)(=O)=O.CN[C@H]1[C@@H](O)[C@H]2O[C@H](O[C@@H]3[C@@H](N)C[C@@H](N)[C@H](O)[C@H]3O)[C@H](N)C[C@@H]2O[C@@H]1O[C@H]4O[C@H](CO)[C@@H](N)[C@H](O)[C@H]4O |
| | Apramycin sulfate Usage And Synthesis |
| Chemical Properties | Pale Yellow Solid | | Uses | antibacterial; LD50(iv) 280mg/kg(mouse) | | Uses | Apramycin sulfate binds to the deep groove of RNA and effectively inhibits ribosomal translocation prohibiting protein synthesis. | | Uses | Apramycin sulfate is a broad spectrum aminocyclitol antibiotic and component of the Nebramycin complex, produced by a strain of Streptomyces tenebrarius. Antibacterial. | | Definition | ChEBI: Apramycin sulfate is a glycoside and an amino cyclitol. | | in vivo | Apramycin (200 mg/kg/d, s.c., 9 d) sulfate demonstrates significant in vivo efficacy in lungs of M. tuberculosis low-dose aerosol infection model IFN-γ knockout mice[2].
Apramycin (16, 32, 80 mg/kg, s.c., 24 h) sulfate dose-dependently reduces bacterial burden in the kidneys between 2-5 log10 and in blood between 2-3 log10 for neutropenic model of Staphylococcus aureus septicemia mice[2].
Apramycin (50 mg/kg/d, s.c., 21 d) sulfate induces nephrotoxicity scores comparable to those induced by Gentamicin (10 mg/kg/d)[3].
| Animal Model: | M. tuberculosis low-dose aerosol infection model of IFN-γ knockout mice [2] | | Dosage: | 200 mg/kg/d | | Administration: | Subcutaneousinjection (s.c.) for 9 d | | Result: | Showed a 2.4-log10 CFU reduction and better antituberculous activity compared to Amikacin (1.8-log10 reduction). |
| | IC 50 | Aminoglycoside |
| | Apramycin sulfate Preparation Products And Raw materials |
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