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| | SUC-PHE-GLU-PRO-ILE-PRO-GLU-GLU-TYR(SO3H)-LEU-D-GLU-OH Basic information |
| Product Name: | SUC-PHE-GLU-PRO-ILE-PRO-GLU-GLU-TYR(SO3H)-LEU-D-GLU-OH | | Synonyms: | SUCCINYL-(PRO58,D-GLU65)-HIRUDIN (56-65) (SULFATED);SUC-PHE-GLU-PRO-ILE-PRO-GLU-GLU-TYR(SO3H)-LEU-D-GLU;SUC-PHE-GLU-PRO-ILE-PRO-GLU-GLU-TYR(SO3H)-LEU-D-GLU-OH;Suc-Phe-Glu-Pro-Ile-Pro-Glu-Glu-Tyr(OSO3H)-Leu-D-Glu-OH;D-Glutamic acid,N-[N-[N-[N-[N-[1-[N-[1-[N-[N-(3-carboxy-1-oxopropyl)-L-phenylalanyl]-L-α-glutamyl]-L-prolyl]-L-isoleucyl]-L-prolyl]-L-α-glutamyl]-L-α-glutamyl]-O-sulfo-L-tyrosyl]-L-leucyl]-;D-Glutamic acid, N-[N-[N-[N-[N-[1-[N-[1-[N-[N-(3-carboxy-1-oxopropyl)-L-phenylalanyl]-L-α-glutamyl]-L-prolyl]-L-isoleucyl]-L-prolyl]-L-α-glutamyl]-L-α-glutamyl]-O-sulfo-L-tyrosyl]-L-leucyl]- (9CI);Suc-F-E-P-I-P-E-Glu-Tyr(OSO3H)-L-DGlu | | CAS: | 131791-98-5 | | MF: | C64H88N10O26S | | MW: | 1445.5 | | EINECS: | | | Product Categories: | | | Mol File: | 131791-98-5.mol |  |
| | SUC-PHE-GLU-PRO-ILE-PRO-GLU-GLU-TYR(SO3H)-LEU-D-GLU-OH Chemical Properties |
| density | 1.413±0.06 g/cm3(Predicted) | | storage temp. | -15°C | | pka | -4.17±0.18(Predicted) | | Sequence | {Suc-Phe}-Glu-Pro-Ile-Pro-Glu-Glu-{Tyr(SO3H)}-Leu-{d-Glu} |
| | SUC-PHE-GLU-PRO-ILE-PRO-GLU-GLU-TYR(SO3H)-LEU-D-GLU-OH Usage And Synthesis |
| Uses | Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is a hirugen-like peptide, and has high affnity for thrombin than Hirugen, with a KD < 100 nM. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is an antithrombotic agent. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) inhibits the thrombin-induced fibrin clot formation with an IC50 value of 0.087 μM[1]. | | References | [1] Dekker RJ, et al. The variable region-1 from tissue-type plasminogen activator confers specificity for plasminogen activator inhibitor-1 to thrombin by facilitating catalysis: release of a kinetic block by a heterologous protein surface loop. J Mol Biol. 1999 Oct 29;293(3):613-27. DOI:10.1006/jmbi.1999.3178
[2] Payne MH, et al. Positional effects of sulfation in hirudin and hirudin PA related anticoagulant peptides. J Med Chem. 1991 Mar;34(3):1184-7. DOI:10.1021/jm00107a043 |
| | SUC-PHE-GLU-PRO-ILE-PRO-GLU-GLU-TYR(SO3H)-LEU-D-GLU-OH Preparation Products And Raw materials |
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