新霉素标液
| 中文名称 | 新霉素标液 |
|---|---|
| 中文同义词 | 新霉素标液;新霉素溶液;新霉素B;新霉素B六乙酸酯;硫酸弗兰西汀(新霉素B);化合物 T15348;新生霉素溶液 T1462 上海瑞楚;新生霉素溶液 T1481 上海瑞楚 |
| 英文名称 | NEOMYCIN B |
| 英文同义词 | Neomycin solution;neomycine standard solution;D-Streptamine, O-2,6-diamino-2,6-dideoxy-.beta.-L-idopyranosyl-(1?3)-O-.beta.-D-ribofuranosyl-(1?5)-O-2,6-diamino-2,6-dideoxy-.alpha.-D-glucopyranosyl-(1?4)-2-deoxy-;NEOMYCIN STANDARD;NEOMYCIN B;actilin;actiline;antibiotique |
| CAS号 | 119-04-0 |
| 分子式 | C23H46N6O13 |
| 分子量 | 614.64 |
| EINECS号 | 204-292-2 |
| 相关类别 | 原料药 API;Mechanism of Action;N;L - ZAlphabetic;NA - NIMore...Close...;AminoglycosidesAntibiotics;Antibacterial;Antibiotics;Antibiotics A to;Antibiotics by Application;Antibiotics N-SAntibiotics;Antineoplastic and Immunosuppressive AntibioticsAntibiotics;Chemical Structure Class;Genetic Marker SelectionAntibiotics;Interferes with Protein SynthesisSpectrum of Activity |
| Mol文件 | 119-04-0.mol |
| 结构式 |  |
新霉素标液 性质
| 熔点 | >194°C (dec.) |
|---|---|
| 沸点 | 658.4°C (rough estimate) |
| 密度 | 1.3548 (rough estimate) |
| 折射率 | 1.6000 (estimate) |
| 储存条件 | 2-8°C |
| 溶解度 | 可溶于酸性水溶液（轻微）、水（轻微） |
| 形态 | 液体 |
| 酸度系数(pKa) | 12.93±0.70(Predicted) |
| 颜色 | 透明的 |
| 生物来源 | Streptomyces fradiae |
| Merck | 13,6482 |
| 稳定性 | 吸湿性 |
| InChIKey | PGBHMTALBVVCIT-VCIWKGPPSA-N |
| SMILES | NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@H]2O[C@@H]3O[C@H](CO)[C@@H](O[C@H]4O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]4N)[C@H]3O)[C@H](N)[C@@H](O)[C@@H]1O |
Ki: 35 μM (RNase P cleavage activity) and 13.5 μM (hammerhead ribozyme)
The inhibition of RNase P RNA cleavage by Framycetin (Neomycin B; Fradiomycin B) is sensitive to pH and an increase in pH suppresses the inhibition in other systems.
Framycetin targets the bacterial and human ribosome and affect translation. 5″-azido neomycin B and Framycetin selectively inhibit production of the mature miRNA, boosts a downstream protein, and inhibits invasion in HCC cell line.
Framycetin binds to a structural rather than a sequence motif of the RNA. Its primary cognate target is the decoding site of the 16S rRNA, but it also binds to the Rev-responsive element in HIV-1, group I introns, and the hammerhead ribozyme, and thus inhibits their biological function.
Framycetin induces misreading of the genetic code during translation and inhibits several ribozymes. The ribosomal target site is the 16 S rRNA 1400 to 1500 region.
安全信息
| 危险品标志 | Xn |
|---|---|
| 危险类别码 | 42/43-63-36/37/38 |
| 安全说明 | 26-36/37/39-45-36/37-23 |
| WGK Germany | 2 |
| F | 8 |
| 存储类别 | 10 - 可燃性液体 |
| 危险性类别 | 呼吸道致敏物 类别1 皮肤致敏物 类别1 |
| 提供商 | 语言 |
|---|---|
|
英文
|