| Company Name: |
BOC Sciences |
| Tel: |
16314854226; +8616314854226 |
| Email: |
inquiry@bocsci.com |
FIDAS-3 manufacturers
- FIDAS-3
-
- $43.00
-
2026-07-15
- CAS:1266684-01-8
- Purity: 98.59%
- Supply Ability: 10g
- FIDAS-3
-
- $43.00
-
2026-07-15
- CAS:1266684-01-8
- Purity: 98.59%
- Supply Ability: 10g
|
| | FIDAS-3 Basic information |
| Product Name: | FIDAS-3 | | Synonyms: | FIDAS-3;FIDAS-3,Inhibitor,Wnt,CyclinD1,anti-proliferation,FIDAS3,FIDAS 3,c-Myc,MAT2A,β-catenin,S-adenosylmethionine,anti-cancer,SAH,inhibit,SAM;Benzenamine, 4-[(1E)-2-(2,6-difluorophenyl)ethenyl]-N,N-dimethyl-;(E)-4-(2,6-Difluorostyryl)-N,N-dimethylaniline;FIDAS-3, 10 mM in DMSO;Wnt Pathway Inhibitor XII;FIDAS-3 ，E0081 | | CAS: | 1266684-01-8 | | MF: | C16H15F2N | | MW: | 259.29 | | EINECS: | | | Product Categories: | | | Mol File: | 1266684-01-8.mol |  |
| | FIDAS-3 Chemical Properties |
| Boiling point | 355.8±30.0 °C(Predicted) | | density | 1.183±0.06 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | DMSO : 100 mg/mL (385.67 mM; Need ultrasonic) | | form | A solid | | pka | 4.68±0.24(Predicted) | | color | off-white to pale yellow |
| WGK Germany | WGK 2 | | Storage Class | 11 - Combustible Solids |
| | FIDAS-3 Usage And Synthesis |
| Uses | FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A). FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities[1][2]. | | Biological Activity | FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A). FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities[1][2].
FIDAS-3 (3 μM; 7 days; LS174T cells) treatment significantly inhibits the proliferation of LS174T cells[1]. FIDAS-3 (3-10 μM) treatment inhibits the expression of c-Myc and cyclinD1 in LS174T CRC cells. And FIDAS-3 induces the expression of cell cycle inhibitor, p21WAF1/CIP1[1]. FIDAS-3 (10 μM; 36 h) treatment reduces the levels of both S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in LS174T cells[1].
FIDAS-3 (20 mg/kg; intraperitoneal injection; daily; for one months; C57BL/6J athymic nude mice) treatment significantly inhibits the growth of xenograft tumors[2]. | | in vivo | FIDAS-3 (20 mg/kg; intraperitoneal injection; daily; for one months; C57BL/6J athymic nude mice) treatment significantly inhibits the growth of xenograft tumors[2]. | Animal Model: | C57BL/6J athymic nude mice (6-8 week) injected with LS174 cells[2] | | Dosage: | 20 mg/kg | | Administration: | Intraperitoneal injection; daily; for one months | | Result: | Significantly inhibited the growth of xenograft tumors.
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| | References | [1]. Zhang W, et al. Fluorinated N,N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2A. ACS Chem Biol. 2013 Apr 19;8(4):796-803. [2]. Zhang W, et al. Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. J Med Chem. 2011 Mar 10;54(5):1288-97. |
| | FIDAS-3 Preparation Products And Raw materials |
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