| Company Name: |
Shanghai YuanYe Biotechnology Co., Ltd.
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| Tel: |
021-61312847; 18021002903 |
| Email: |
3008007409@qq.com |
| Products Intro: |
Product Name:Vantictumab (anti-FZD)
CAS:1345009-45-1
Purity:ExactAb?, Validated, Carrier Free, Low Endotoxin, Azide Free Package:5mg Remarks:K10786
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| Company Name: |
ShangHai Biochempartner Co.,Ltd
|
| Tel: |
177-54423994 17754423994 |
| Email: |
2853530910@QQ.com |
| Products Intro: |
Product Name:Vantictumab
CAS:1345009-45-1
Purity:95% Package:100ug;500ug;1mg
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| Company Name: |
Guangzhou Hongyuan Chemical Co.,Ltd
|
| Tel: |
15817493340 |
| Email: |
981810490@qq.com |
| Products Intro: |
Product Name:Vantictumab
CAS:1345009-45-1
Purity:95% Package:1mg;1g;100g
|
Vantictumab manufacturers
- Vantictumab
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- $247.00 / 1mg
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2026-04-22
- CAS:1345009-45-1
- Min. Order:
- Purity: 99% (SDS-PAGE); 97.7% (SEC-HPLC)
- Supply Ability: 10g
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| | Vantictumab Basic information |
| Product Name: | Vantictumab | | Synonyms: | Vantictumab;Research Grade Vantictumab (DHJ82501);Vantictumab (anti-FZD);Research Grade Vantictumab | | CAS: | 1345009-45-1 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![Vantictumab Structure]() |
| | Vantictumab Chemical Properties |
| form | Liquid | | color | Colorless to light yellow |
| | Vantictumab Usage And Synthesis |
| Uses | Vantictumab (OMP-18R5) is a fully human IgG2 monoclonal antibody. Vantictumab inhibits Wnt pathway signaling by binding to FZD1/2/5/7/8 receptors. Vantictumab can be studied against cancers through direct actions on tumor cells, including CSCs, and effects on the stroma, such as metastatic HER2-negative breast cancer and metastatic pancreatic adenocarcinoma[1][2][3]. | | References | [1] Davis SL, et al. A phase 1b dose escalation study of Wnt pathway inhibitor vantictumab in combination with nab-paclitaxel and gemcitabine in patients with previously untreated metastatic pancreatic cancer. Invest New Drugs. 2020 Jun;38(3):821-830. DOI:10.1007/s10637-019-00824-1
[2] Diamond JR, et al. Phase Ib clinical trial of the anti-frizzled antibody vantictumab (OMP-18R5) plus paclitaxel in patients with locally advanced or metastatic HER2-negative breast cancer. Breast Cancer Res Treat. 2020 Nov;184(1):53-62. DOI:10.1007/s10549-020-05817-w
[3] Smith D C, et al. Abstract B24: Biomarker analysis in the first-in-human phase 1a study for vantictumab (OMP-18R5; anti-Frizzled) demonstrates pharmacodynamic (PD) modulation of the Wnt pathway in patients with advanced solid tumors[J]. Molecular Cancer Therapeutics, 2013, 12(11_Supplement): B24-B24. |
| | Vantictumab Preparation Products And Raw materials |
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