2-TRIFLUOROMETHYL-PYRIMIDINE-5-CARBALDEHYDE manufacturers
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| | 2-TRIFLUOROMETHYL-PYRIMIDINE-5-CARBALDEHYDE Basic information |
| Product Name: | 2-TRIFLUOROMETHYL-PYRIMIDINE-5-CARBALDEHYDE | | Synonyms: | 2-TRIFLUOROMETHYL-PYRIMIDINE-5-CARBALDEHYDE;2-(Trifluoromethyl)pyrimidine-5-carbaldehydec;2-Trifluoromethyl-5-formylpyrimidine;2-Trifluoromethyl-5-pyrimidinecarboxaldehyde;2-（trifluromethyl）pyridine-5-carbaldehyde;5-Pyrimidinecarboxaldehyde,2-(trifluoromethyl)-;2-TRIFLUOROMETHYL-PYRIMIDINE-5-CARBALDEHYDE ISO 9001：2015 REACH | | CAS: | 304693-66-1 | | MF: | C6H3F3N2O | | MW: | 176.1 | | EINECS: | | | Product Categories: | Fluorine series | | Mol File: | 304693-66-1.mol |  |
| | 2-TRIFLUOROMETHYL-PYRIMIDINE-5-CARBALDEHYDE Chemical Properties |
| Boiling point | 153℃ | | density | 1.454 | | Fp | 47℃ | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | -3.47±0.22(Predicted) | | Appearance | White to light yellow Solid | | InChI | InChI=1S/C6H3F3N2O/c7-6(8,9)5-10-1-4(3-12)2-11-5/h1-3H | | InChIKey | GAUDQBASERVUGM-UHFFFAOYSA-N | | SMILES | C1(C(F)(F)F)=NC=C(C=O)C=N1 |
| | 2-TRIFLUOROMETHYL-PYRIMIDINE-5-CARBALDEHYDE Usage And Synthesis |
| Synthesis | Step B: Synthesis of 2-(trifluoromethyl)pyrimidine-5-carbaldehyde
To a solution of ethyl 2-(trifluoromethyl)pyrimidine-5-carboxylate (25.5 g, 116.0 mmol) in dichloromethane (580 mL) was slowly added diisobutylaluminum hydride (1.0 M, 130.0 mL, 130.0 mmol) at -78 °C. The reaction mixture was kept stirred at -78 °C for 2 hours. Subsequently, the reaction was quenched by slow addition of hydrochloric acid (2.0 M). The mixture was gradually warmed up to ambient temperature. The mixture was extracted with ether (3 times). The organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated to give the target product 2-(trifluoromethyl)pyrimidine-5-carbaldehyde (28.2 g). | | References | [1] Patent: US2004/167142, 2004, A1. Location in patent: Page/Page column 23;24
[2] Patent: TW2016/5858, 2016, A. Location in patent: Page/Page column 133; 134
[3] Patent: US2014/107335, 2014, A1. Location in patent: Paragraph 0091; 0092
[4] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 1, p. 51 - 55
[5] Patent: WO2010/111058, 2010, A1. Location in patent: Page/Page column 69 |
| | 2-TRIFLUOROMETHYL-PYRIMIDINE-5-CARBALDEHYDE Preparation Products And Raw materials |
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