vinconate manufacturers
- Vinconate
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- $2500.00
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2026-05-11
- CAS:70704-03-9
- Purity:
- Supply Ability: 10g
- Vinconate
-
- $2500.00
-
2025-07-17
- CAS:70704-03-9
- Purity:
- Supply Ability: 10g
- vinconate
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- $1.00
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2019-12-27
- CAS:70704-03-9
- Min. Order: 1KG
- Purity: 97%-99.9%
- Supply Ability: 100kg
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| | vinconate Basic information |
| Product Name: | vinconate | | Synonyms: | vinconate;Vintenate;Chanodesethylapovinc?amine;Vincote;1H-Indolo[3,2,1-de][1,5]naphthyridine-6-carboxylic acid, 3-ethyl-2,3,3a,4-tetrahydro-, methyl ester | | CAS: | 70704-03-9 | | MF: | C18H20N2O2 | | MW: | 296.368 | | EINECS: | 2747897 | | Product Categories: | | | Mol File: | 70704-03-9.mol |  |
| | vinconate Chemical Properties |
| Melting point | 120-121° | | Boiling point | 363.6±42.0 °C(Predicted) | | density | 1.27±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 8.00±0.40(Predicted) |
| | vinconate Usage And Synthesis |
| Uses | Vinconate is an indolonaphthyridine derivative and can stimulate the muscariic acetylcholine receptor. | | in vivo | Treatment with Vinconate (50 to 200 mg/kg p.o.) significantly increases dopamine concentrations in dialysate. Daily treatment with Vinconate (25 mg/kg) for 7 days also significantly increases dopamine and serotonin concentrations in dialysate[1]. Chronic treatment with Vinconate at a 10 mg/kg significantly ameliorats the reduction in [3H]QNB binding in the nucleus accumbens and cerebellum. Furthermore, this Vinconate treatment significantly enhances [3H]QNB binding in the frontal cortex and hippocampus compare with the vehicle-treated aged animals. Also, chronic treatment with Vinconate at the higher dose significantly elevates [3H]QNB binding in the hippocampal CA3 sector and dentate gyrus compare with the vehicle-treated aged animals. Chronic treatment with Vinconate at a dose of 10 mg/kg shows a significant reduction in [3H]HC binding only in the hippocampal CA1 sector compare with the vehicle-treated aged rats[2]. | | References | [1] Iino T, et al. Effect of vinconate, an indolonaphthyridine derivative, on dopamine and serotonin concentrations in dialysate from the striatum of freely moving rats: brain microdialysis studies. J Pharmacol Exp Ther. 1996 Aug;278(2):614-9. PMID:8768711
[2] Araki T, et al. Effects of vinconate on neurotransmitter receptor systems in aged rat brain. Environ Toxicol Pharmacol. 1996 Dec 20;2(4):343-9. DOI:10.1016/s1382-6689(96)00068-3 |
| | vinconate Preparation Products And Raw materials |
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