|
|
| | 4-acetylpiperidinium chloride Basic information |
| Product Name: | 4-acetylpiperidinium chloride | | Synonyms: | 4-acetylpiperidinium chloride;4-Acetylpiperidine hydrochloride,98%;1-(4-Piperidinyl)ethanone hydrochloride;1-(4-Piperidyl)ethanone Hydrochloride;4-Acetylpiperidine hydrochloride;1-(Piperidin-4-yl)ethanone hydrochloride;ETHANONE,1-(4-PIPERIDINYL)-,HYDROCHLORIE (1 : 1);1-(Piperidin-4-yl)ethanone, HCl | | CAS: | 89895-06-7 | | MF: | C7H14ClNO | | MW: | 163.65 | | EINECS: | 289-528-2 | | Product Categories: | | | Mol File: | 89895-06-7.mol |  |
| | 4-acetylpiperidinium chloride Chemical Properties |
| Melting point | 151-158°C | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | color | White to Off-White |
| | 4-acetylpiperidinium chloride Usage And Synthesis |
| Uses | 1-(4-Piperidinyl)ethanone is used in the synthesis of oral antagonists for the treatment of rheumatoid arthritis. Also used in the synthesis of p38 mitogen activated protein kinase. | | Synthesis | General procedure for the synthesis of 1-(4-piperidinyl)ethanone hydrochloride from 1-N-BOC-4-acetylpiperidine: To an anhydrous dichloromethane (5 mL) solution of 1-N-BOC-4-acetylpiperidine (350 mg, 1.54 mmol) was slowly added a dioxane solution (2 mL) of 4 M HCl at 0 °C. The reaction mixture was stirred continuously at 0°C for 2 hours. Upon completion of the reaction, the mixture was concentrated by rotary evaporator to afford 1-(4-piperidinyl)ethanone hydrochloride (260 mg, 100% yield) as a white solid, which could be used directly in the subsequent reaction without further purification. | | References | [1] Patent: WO2013/96744, 2013, A1. Location in patent: Page/Page column 192
[2] Patent: EP3255042, 2017, A2. Location in patent: Paragraph 0209; 0213 |
| | 4-acetylpiperidinium chloride Preparation Products And Raw materials |
|