- 2-PMPA
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- $61.00
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2026-07-27
- CAS:173039-10-6
- Purity: 97.40%
- Supply Ability: 10g
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| | PMPA(NAALADaseinhibitor) Basic information |
| Product Name: | PMPA(NAALADaseinhibitor) | | Synonyms: | PMPA(NAALADaseinhibitor);2-(Phosphonomethyl)pentane-1,5-dioicacid;CS-2454;2-PMPA(NAALADaseinhibitor);NAALADASEINHIBITOR;Pentanedioic acid, 2-(phosphonomethyl)-;2-(PHOSPHONOMETHYL)PENTANEDIOIC ACID (PMPA);inhibit,Inhibitor,2PMPA,Carboxypeptidase,2-PMPA,2 PMPA | | CAS: | 173039-10-6 | | MF: | C6H11O7P | | MW: | 226.12 | | EINECS: | | | Product Categories: | | | Mol File: | 173039-10-6.mol |  |
| | PMPA(NAALADaseinhibitor) Chemical Properties |
| Boiling point | 538.8±60.0 °C(Predicted) | | density | 1.658±0.06 g/cm3(Predicted) | | storage temp. | room temp | | solubility | Soluble to 100 mM in sterile | | form | powder | | pka | 2.06±0.10(Predicted) | | color | white to beige | | Water Solubility | Soluble to 100 mM in water | | InChI | 1S/C6H11O7P/c7-5(8)2-1-4(6(9)10)3-14(11,12)13/h4H,1-3H2,(H,7,8)(H,9,10)(H2,11,12,13) | | InChIKey | ISEYJGQFXSTPMQ-UHFFFAOYSA-N | | SMILES | O=C(O)CCC(C(O)=O)CP(O)(O)=O |
| WGK Germany | WGK 3 | | RTECS | SA0454800 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2 |
| | PMPA(NAALADaseinhibitor) Usage And Synthesis |
| Uses | 2-(Phosphonomethyl)pentanedioic Acid is a selective glutamate carboxypeptidase 2 (GCP-II) inhibitor, the enzyme which catabolizes the abundant neuropeptide N-acetyl-aspartyl-glutamate (NAAG) to N-acetylaspartate (NAA) and glutamate. A posiible target in the treatment of multiple sclerosis and Schizophrenia. | | Biological Activity | Highly potent and selective inhibitor of glutamate carboxypeptidase 2 (GCP II/N-acetylated α -linked dipeptidase/NAALADase) with a K i value of 275 pM. Neuroprotective; protects against glutamate-mediated motor neuron degeneration and reduces volume of injury following middle cerebral artery occlusion (MCAO). | | Biochem/physiol Actions | 2-PMPA is a potent and selective inhibitor of Glutamate carboxypeptidase II (GCPII). | | in vivo | Intraperitoneal administration of 100 mg/kg 2-PMPA results in maximum concentration in plasma of 275 μg/mL at 0.25 h. The half-life, area under the curve, apparent clearance, and volume of distribution are 0.64 h, 210 μg×h/mL, 7.93 mL/min/kg, and 0.44 L/kg, respectively[1]. 2-PMPA at 250 mg/kg, in an anesthetized mouse, after an initial rise, produces a rapid decline and a striking attenuation in BOLD signals in gray matter. The signature of 2-PMPA on brain T2* signals in gray matter at both 167 and 250 mg/kg includes a significant initial rise lasting several minutes[3]. 2-PMPA has neuroprotective activity in an animal model of stroke and anti-allodynic activity in CCI model. Administration of 2-PMPA (50mg/kg) produces a mean peak concentration of 2-PMPA of 29.66±8.1 μM. This concentration is about 100,000 fold more than is needed for inhibition of NAAG peptidase, and indicates very good penetration to the brain. Administration of 50 mg/kg 2-PMPA (i.p.) produces a continuously increasing extracellular NAAG concentration, which startes directly after application[4]. | | storage | Desiccate at RT |
| | PMPA(NAALADaseinhibitor) Preparation Products And Raw materials |
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