| Company Name: |
Energy Chemical |
| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing@energy-chemical.com |
Nocloprost manufacturers
- Nocloprost
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- $855.00
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2026-08-30
- CAS:79360-43-3
- Purity:
- Supply Ability: 10g
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| | Nocloprost Basic information |
| Product Name: | Nocloprost | | Synonyms: | Nocloprost;(5Z,13E,15R)-9β-Chloro-11α,15-dihydroxy-16,16-dimethylprosta-5,13-dien-1-oic acid;SH-475;Prosta-5,13-dien-1-oic acid, 9-chloro-11,15-dihydroxy-16,16-dimethyl-, (5Z,9β,11α,13E,15R)-;Prosta-5,13-dien-1-oicacid, 9-chloro-11,15-dihydroxy-16,16-dimethyl-, (5Z,9b,11a,13E,15R)- | | CAS: | 79360-43-3 | | MF: | C22H37ClO4 | | MW: | 400.98 | | EINECS: | | | Product Categories: | | | Mol File: | 79360-43-3.mol |  |
| | Nocloprost Chemical Properties |
| Boiling point | 539.8±50.0 °C(Predicted) | | density | 1.10±0.1 g/cm3(Predicted) | | solubility | DMF: 11 mg/ml; DMSO: 10 mg/ml; Ethanol: 16 mg/ml; Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml | | pka | 4.76±0.10(Predicted) |
| | Nocloprost Usage And Synthesis |
| Uses | Nocloprost is a synthetic prostaglandin E (P838610) analogue which can stimulate adenylate cyclase enzyme. Nocloprost was also studied as mucosal protective drug. | | in vivo | Nocloprost (intragastrically; 0.01-10 μg/kg) 30 min before 100% ethanol, acidified Aspirin (HY-14654), acidified Taurocholate (HY-N0545), water immersion, or restraint stress dose dependently prevents the formation of gastric lesions in rats[1].
Nocloprost (i.g.; 0.01-100 μg/kg) failes to affect gastric acid secretion or intestinal secretion (enteropooling) but preventes the increased gastroduodenal alkaline secretion[1].
Nocloprost (s.c.) shows protective activity against ethanol damage but is ineffective when applied intraduodenally[1].
| Animal Model: | 220-250 g rats[1] | | Dosage: | 0.01-10 μg/kg | | Administration: | Intragastrically; single dose | | Result: | 30 min before 100% ethanol, acidified Aspirin (ASA), acidified Taurocholate, water immersion, or restraint stress dose dependently prevented the formation of gastric lesions, the ID50 values being 0.25, 0.58, 0.06 and 0.12 μg/kg in rats, respectively.
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| | IC 50 | EP1; EP3 |
| | Nocloprost Preparation Products And Raw materials |
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