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| | Quinolin-3-yl-methanol Basic information |
| | Quinolin-3-yl-methanol Chemical Properties |
| storage temp. | Sealed in dry,Room Temperature | | Boiling point | 329.8±17.0 °C(Predicted) | | density | 1.218±0.06 g/cm3(Predicted) | | Melting point | 65-67 °C | | pKa | 13.68±0.10(Predicted) | | Appearance | Off-white to light yellow Solid |
| | Quinolin-3-yl-methanol Usage And Synthesis |
| Synthesis | Step 1: Sodium borohydride (240 mg, 6.4 mmol) was added batchwise to a solution of quinoline-3-carbaldehyde (910 mg, 5.8 mmol) in methanol (10 mL) at room temperature. The reaction mixture was stirred for 3 hours and then the reaction was quenched with saturated aqueous ammonium chloride solution (10 mL). Subsequently, the reaction mixture was extracted with ethyl acetate (3 x 30 mL). The organic phases were combined, washed with brine and dried with anhydrous magnesium sulfate. After filtration, the filtrate was concentrated under reduced pressure to afford the crude quinolin-3-ylmethanol (795 mg, 86% yield). | | References | [1] Journal of Organic Chemistry, 1990, vol. 55, # 19, p. 5344 - 5347
[2] European Journal of Organic Chemistry, 2009, # 26, p. 4458 - 4467
[3] Patent: WO2008/115516, 2008, A2. Location in patent: Page/Page column 65
[4] Patent: WO2005/123724, 2005, A1. Location in patent: Page/Page column 73
[5] Heterocycles, 1999, vol. 51, # 8, p. 1883 - 1889 |
| | Quinolin-3-yl-methanol Preparation Products And Raw materials |
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