1-Naphthol-3,6,8-trisulfonic acid trisodium salt

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1-Naphthol-3,6,8-trisulfonic acid trisodium salt Basic information
Product Name:1-Naphthol-3,6,8-trisulfonic acid trisodium salt
Synonyms:1,3,6-Naphthalenetrisulfonic acid, 8-hydroxy-, trisodium salt;Zeta-Stat trisodium;ζ-Stat trisodium;NSC37044 trisodium;I-Stat (trisodium);1-Naphthol-3,6,8-trisulfonic acid trisodium salt
CAS:31894-34-5
MF:C10H5Na3O10S3
MW:450.31
EINECS:
Product Categories:
Mol File:31894-34-5.mol
1-Naphthol-3,6,8-trisulfonic acid trisodium salt Structure
1-Naphthol-3,6,8-trisulfonic acid trisodium salt Chemical Properties
form Solid
color Light yellow to light brown
Safety Information
MSDS Information
1-Naphthol-3,6,8-trisulfonic acid trisodium salt Usage And Synthesis
Usesζ-Stat trisodium (NSC37044 trisodium) is a specific and atypical PKC-ζ inhibitor, with an IC50 of 5 μM. ζ-Stat trisodium can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitro[1][2].
IC 50aPKC-ζ: 5 μM (IC50)
References[1] Ratnayake WS, et, al. Oncogenic PKC-ι activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-ι and PKC-ζ specific inhibitors. Cell Adh Migr. 2018; 12(5):447-463. DOI:10.1080/19336918.2018.1471323
[2] Islam SMA, et, al. Atypical Protein Kinase-C inhibitors exhibit a synergistic effect in facilitating DNA damaging effect of 5-fluorouracil in colorectal cancer cells. Biomed Pharmacother. 2020 Jan; 121:109665. DOI:10.1016/j.biopha.2019.109665
1-Naphthol-3,6,8-trisulfonic acid trisodium salt Preparation Products And Raw materials
Tag:1-Naphthol-3,6,8-trisulfonic acid trisodium salt(31894-34-5) Related Product Information
1-Naphthol-3,6,8-trisulfonic acid trisodium salt 1,3,6-Naphthalenetrisulfonic acid, sodium salt, hydrate, mixture of isomers 1-Naphthol-8-sulfonic acid sodium salt 1-Naphthol-3,8-disulfonic acid 1-Naphthol-3,8-disulfonic acid disodium salt 1,6-Naphthalenedisulfonic acid disodium salt tetrasodium [8-hydroxy-7-[[2-hydroxy-5-methyl-4-[[3-[[2-(sulphooxy)ethyl]sulphonyl]phenyl]azo]phenyl]azo]naphthalene-1,3,6-trisulphonato(6-)]cuprate(4-) DIRECT VIOLET 22 1-Hydroxynaphthalene-8-sulfonic acid 1,3,(6,7)-Naphthalenetrisulfonic acid trisodium salt hydrate