FK-3311 manufacturers
- FK 3311
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- $37.00
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2026-05-11
- CAS:116686-15-8
- Purity: 97.98%
- Supply Ability: 10g
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| | FK-3311 Basic information |
| Product Name: | FK-3311 | | Synonyms: | FK-3311;N-[4-Acetyl-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide;N-[4-Acetyl-2-(2,4-difluorophenoxy)phenyl]-methanesulfonamide FK3311;COX-2 Inhibitor V, FK3311;CS-1073;FK-3311; FK3311;COX-2 Inhibitor V;Methanesulfonamide, N-[4-acetyl-2-(2,4-difluorophenoxy)phenyl]- | | CAS: | 116686-15-8 | | MF: | C15H13F2NO4S | | MW: | 341.33 | | EINECS: | | | Product Categories: | | | Mol File: | 116686-15-8.mol |  |
| | FK-3311 Chemical Properties |
| Boiling point | 431.3±55.0 °C(Predicted) | | density | 1.419±0.06 g/cm3(Predicted) | | storage temp. | Store at RT | | solubility | Soluble in DMSO | | form | White solid | | pka | 6.82±0.10(Predicted) | | color | Light yellow to yellow | | InChI | 1S/C15H13F2NO4S/c1-9(19)10-3-5-13(18-23(2,20)21)15(7-10)22-14-6-4-11(16)8-12(14)17/h3-8,18H,1-2H3 | | InChIKey | DIIYLGZNZGPXRR-UHFFFAOYSA-N | | SMILES | Fc1c(ccc(c1)F)Oc2c(ccc(c2)C(=O)C)N[S](=O)(=O)C |
| WGK Germany | WGK 1 | | Storage Class | 11 - Combustible Solids |
| | FK-3311 Usage And Synthesis |
| Uses | COX-2 Inhibitor V, FK3311 is a selective Cox-2 inhibitor and NSAID. | | Biological Activity | Cyclooxygenase-2 (COX-2) inhibitor. Inhibits zymosan-induced prostaglandin E 2 production by rat peritoneal neutrophils in vitro and adjuvant-induced arthritis in vivo . Anti-inflammatory. | | in vivo | L-PVR, CO, PaO(2), and WDR were significantly better in the FK group than in the control group. Histological tissue edema was mild, and PMN infiltration was significantly reduced in the FK group compared to the control group. The serum TxB(2) levels were significantly lower in the FK group than in the control group, while 6-keto-PGF(1alpha) levels were not significantly reduced. Two-day survival rate was significantly better in the FK group than in the control group[2].
Survival rate was significantly better and serum GOT levels 30 min after reperfusion were significantly lower in the FK high-dose group compared to the other two groups. Four hours after reperfusion, GPT levels and liver tissue flow were significantly better in the FK high-dose group compared to the control. Both 30 min and 4 hr after reperfusion, serum TxB(2) levels were significantly lower in the FK high-dose group compared to the control[3].
| | IC 50 | COX-2 |
| | FK-3311 Preparation Products And Raw materials |
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