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| | Glycine, N-D-γ-glutamyl-, mono(trifluoroacetate) (9CI) Basic information |
| | Glycine, N-D-γ-glutamyl-, mono(trifluoroacetate) (9CI) Chemical Properties |
| solubility | Water: Soluble | | form | A solid | | Water Solubility | Water: soluble |
| | Glycine, N-D-γ-glutamyl-, mono(trifluoroacetate) (9CI) Usage And Synthesis |
| Description | γ-D-Glutamylglycine (γ-DGG) is an antagonist of the excitatory amino acids NMDA , quisqualate, kainate, and glutamate.1 It decreases the amplitude of excitatory post-synaptic potentials (EPSPs) in electrically stimulated rat hippocampal slices when used at a concentration of 200 mM. Subdural administration of γ-DGG inhibits NMDA-, kainate-, or quisqualate-induced paw biting, indicating antinociceptive activity, in mice (EC50s = 63, 9.5, and 31 μM, respectively).2 γ-DGG reduces sound-induced wild running and inhibits the clonic and tonic phases of sound-induced seizures in DBA/2 mice (ED50s = 0.058, 0.046, and 0.054 μmol, i.c.v., respectively).3 | | Uses | gamma-DGG TFA is the antagonist for excitatory amino acid, that blocks NMDA-(HY-17551), Kainate-(HY-N2309) and Quisqualate-(HY-12597) induced depolarization, and antagonises the excitatory postsynaptic potential (e.p.s.p.) in rat hippocampal slices[1]. | | References | [1] Crunelli, S., Forda, S., and Kelly, J.S. Blockade of amino acid-induced depolarizations and inhibition of excitatory post-synaptic potentials in rat dentate gyrus J. Physiol. 341,627-640(1983).
[2] Raigorodsky, G., and Urca, G. Spinal antinociceptive effects of excitatory amino acid antagonists: Quisqualate modulates the action of N-methyl-D-aspartate Eur. J. Pharmacol. 182(1),37-47(1990).
[3] Croucher, M.J., Collins, J.F., and Meldrum, B.S. Anticonvulsant action of excitatory amino acid antagonists Science 216(4548),899-901(1982). |
| | Glycine, N-D-γ-glutamyl-, mono(trifluoroacetate) (9CI) Preparation Products And Raw materials |
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