5-vinyl-2'-deoxyuridine manufacturers
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| | 5-vinyl-2'-deoxyuridine Basic information |
| Product Name: | 5-vinyl-2'-deoxyuridine | | Synonyms: | 5-vinyl-2'-deoxyuridine;2'-Deoxy-5-vinyluridine;2'-Deoxy-5-ethenyluridine;5-vinyldeoxyuridine;5-VINYLDEOXYURIDINE; 2'-DEOXY-5-ETHENYLURIDINE; 5-VINYL-DURD; 2'-DEOXY-5-VINYLURIDINE;5-Vinyl-dUrd;5-Vinyl-2'-deoxyuridine (5-VdU);Uridine, 2'-deoxy-5-ethenyl- | | CAS: | 55520-67-7 | | MF: | C11H14N2O5 | | MW: | 254.24 | | EINECS: | | | Product Categories: | | | Mol File: | 55520-67-7.mol |  |
| | 5-vinyl-2'-deoxyuridine Chemical Properties |
| Melting point | 106-110 °C (decomp) | | Boiling point | 397.45°C (rough estimate) | | density | 1.2983 (rough estimate) | | refractive index | 1.5700 (estimate) | | solubility | soluble in DMSO | | pka | 9.07±0.10(Predicted) | | form | Solid | | Appearance | yellowish solid |
| | 5-vinyl-2'-deoxyuridine Usage And Synthesis |
| Description | VdU (5-Vinyl-2’-deoxyuridine) is a synthetic analog of thymidine that can be used to study de novo DNA synthesis and cell proliferation. It is a potential replacement for BrdU (5-Bromo-2’-deoxyuridine) or EdU (5-Ethynyl-2’-deoxyuridine).
VdU incorporates into replicating DNA during the S-phase of the cell cycle instead of natural thymidine. The resulting vinyl-functionalized DNA can be detected by introducing either a biotin or fluorescent dye group via a cooper-free alkene-tetrazine reaction (also known as Inverse electron demand Diels-Alder ligation or IEDDA) and used for subsequent DNA purification or cell imaging tasks. | | Uses | 5-Vinyl-2'-deoxyuridine (5-VINYL-DURD), a thymidine analogue, is incorporated into cellular DNA during DNA replication. 5-Vinyl-2'-deoxyuridine is a click chemistry reagent, it contains an Alkyne group and induces DNA damage leads to apoptosis in human cultured cells[1]. | | References | [1] Yizhu Li, et al. DNA templated Click Chemistry via 5-vinyl-2'-deoxyuridine and an acridine-tetrazine conjugate induces DNA damage and apoptosis in cancer cells. Life Sci. 2023 Oct 1:330:122000. DOI:10.1016/j.lfs.2023.122000 |
| | 5-vinyl-2'-deoxyuridine Preparation Products And Raw materials |
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