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| | 1-N-Boc-3-Cyanopyrrolidine Basic information |
| Product Name: | 1-N-Boc-3-Cyanopyrrolidine | | Synonyms: | TERT-BUTYL 3-CYANOPYRROLIDINE-1-CARBOXYLATE;3-CYANO-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-N-BOC-3-CYANO-PYRROLIDINE;1-Boc-3-cyanopyrrolidine;N-Boc-3-cyanopyrrolidine;N-1-BOC-3-CYANOPYRROLIDINE;1,1-Dimethylethyl 3-cyano-1-pyrrolidinecarboxylate;1-Pyrrolidinecarboxylic acid, 3-cyano-, 1,1-dimethylethyl ester | | CAS: | 476493-40-0 | | MF: | C10H16N2O2 | | MW: | 196.25 | | EINECS: | | | Product Categories: | Pyrrole&Pyrrolidine&Pyrroline;Organic acids | | Mol File: | 476493-40-0.mol |  |
| | 1-N-Boc-3-Cyanopyrrolidine Chemical Properties |
| Boiling point | 307.9±35.0 °C(Predicted) | | density | 1.08±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | form | solid | | pka | -3.73±0.40(Predicted) | | color | Pale yellow | | CAS DataBase Reference | 476493-40-0(CAS DataBase Reference) |
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ALFA
| English |
| | 1-N-Boc-3-Cyanopyrrolidine Usage And Synthesis |
| Uses | 1-N-Boc-3-cyanopyrrolidine is used to prepare aroyl-substituted pyrrolidines with monoamine reuptake inhibition activities. | | Synthesis | A solution was prepared from tert-butyl 3-(methylsulfonyloxy)pyrrolidine-1-carboxylate (2.65 g, 10 mmol) and sodium cyanide (2.5 g, 50 mmol) in N,N-dimethylformamide (100 mL). The reaction mixture was stirred at 100°C for 16 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was poured into water and extracted with ethyl acetate. The organic phases were combined, washed sequentially with water and saturated saline and dried over anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure and the resulting residue was purified by column chromatography (eluent: petroleum ether/ethyl acetate=5:1) to afford 1-N-Boc-3-cyanopyrrolidine (1.92 g, 98% yield). | | References | [1] Patent: CN107474024, 2017, A. Location in patent: Paragraph 0385; 0392; 0393; 0394
[2] Patent: WO2017/211759, 2017, A1. Location in patent: Page/Page column 59; 60 |
| | 1-N-Boc-3-Cyanopyrrolidine Preparation Products And Raw materials |
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