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| | 1-(2-chloro-4-hydroxyphenyl)-tert-butylaminoethanol Basic information |
| Product Name: | 1-(2-chloro-4-hydroxyphenyl)-tert-butylaminoethanol | | Synonyms: | 1-(2-chloro-4-hydroxyphenyl)-tert-butylaminoethanol;4-Hydroxytulobuterol;Benzenemethanol,2-chloro-a-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-;HOKU 81;2-Chloro-α-[(tert-butylamino)methyl]-4-hydroxybenzenemethanol;2-Chloro-alpha-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxybenzenemethanol;4-HYDROXYTULOBUTEROL; HOKU 81; HOKU81;Benzenemethanol, 2-chloro-α-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy- | | CAS: | 58020-43-2 | | MF: | C12H18ClNO2 | | MW: | 243.73 | | EINECS: | | | Product Categories: | | | Mol File: | 58020-43-2.mol |  |
| | 1-(2-chloro-4-hydroxyphenyl)-tert-butylaminoethanol Chemical Properties |
| Boiling point | 392.026±37.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.184±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 50 mg/mL (205.15 mM; Need ultrasonic) | | form | Powder | | pka | 8.846±0.31(predicted) | | color | White to off-white |
| | 1-(2-chloro-4-hydroxyphenyl)-tert-butylaminoethanol Usage And Synthesis |
| Uses | HOKU-81 (4-Hydroxytulobuterol) is one of the metabolites of Tulobuterol (HY-B1810). HOKU-81 is a potent and selective β2-adrenoceptor stimulant. HOKU-81 has bronchodilating effect[1][2]. | | IC 50 | Beta-2 adrenergic receptor | | References | [1] Kubo S, Matsubara I, Yamazaki M et al. Pharmacological studies of 1-(2-chloro-4-hydroxyphenyl)-2-t-butylaminoethanol (HOKU-81), a new bronchodilator. 1st Communication: Bronchodilator and cardiovascular actions. Arzneimittelforschung. 1980;30(8):1272-8. PMID:7192141
[2] Gomi Y, Shirahase H, Funato H. Effects of 1-(2-chloro-4-hydroxyphenyl)-t-butylaminoethanol (HOKU-81), a new bronchodilator, on isolated trachea and atria of guinea pig. Jpn J Pharmacol. 1979 Aug;29(4):515-24. DOI:10.1254/jjp.29.515 |
| | 1-(2-chloro-4-hydroxyphenyl)-tert-butylaminoethanol Preparation Products And Raw materials |
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