WIZ degrader 4

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WIZ degrader 4 Suppliers list
Company Name: Alfa Chemistry  
Tel: +1-5166625404;
Email: Info@alfa-chemistry.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: ChemOrigin Pharm  
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WIZ degrader 4 Basic information
Product Name:WIZ degrader 4
Synonyms:WIZ degrader 4;2,6-Piperidinedione, 3-[5-[[(3R)-1-ethyl-3-piperidinyl]oxy]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-;Novartis' WIZ degrader (Example 1)
CAS:2879250-22-1
MF:C20H25N3O4
MW:371.43
EINECS:
Product Categories:
Mol File:2879250-22-1.mol
WIZ degrader 4 Structure
WIZ degrader 4 Chemical Properties
Boiling point 629.816±55.00 °C(Press: 760.00 Torr)(predicted)
density 1.279±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka10.781±0.40(predicted)
Safety Information
MSDS Information
WIZ degrader 4 Usage And Synthesis
UsesWIZ degrader 4 (Example 1) is a WIZ degrader with an AC50 value of 160 nM. WIZ degrader 4 can be used to investigate sickle cell disease (SCD) and thalassemia[1].
References[1] Simone BONAZZI, et al. 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and medical uses thereof. WO2022254362A1.2022-12-08.
WIZ degrader 4 Preparation Products And Raw materials
Tag:WIZ degrader 4(2879250-22-1) Related Product Information
1H-Isoindole-1,3(2H)-dione, 4-[(5-aminopentyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) 1H-Isoindole-1,3(2H)-dione, 5-[(14-amino-3,6,9,12-tetraoxatetradec-1-yl)oxy]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) Acetamide, N-(5-aminopentyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]oxy]-, hydrochloride (1:1) 1H-Isoindole-1,3(2H)-dione, 5-(3-aminopropoxy)-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) Pomalidomide-O-C4-NH2 E3 Ligase Ligand-Linker Conjugates 20