Lipid HTO12

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Lipid HTO12 Suppliers list
Company Name: Guangzhou Younan Technology Co., Ltd  
Tel: 020-82000279 18988941452
Email: YN_research@163.com
Company Name: Shochem(Shanghai)Co.,Ltd  
Tel: +86-021-50800795 13816874662
Email: info@shochem.com
Company Name: TargetMol  
Tel: 400-821-0310 15002144251
Email: xuexiang.shao@tsbiochem.com
Lipid HTO12 Basic information
Product Name:Lipid HTO12
Synonyms:Lipid HTO12
CAS:3047222-45-4
MF:C41H83NO4
MW:654.1
EINECS:
Product Categories:
Mol File:3047222-45-4.mol
Lipid HTO12 Structure
Lipid HTO12 Chemical Properties
Boiling point 703.061±45.00 °C(Press: 760.00 Torr)(predicted)
density 0.919±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
solubility Ethanol: Soluble: =10 mg/ml
pka14.735±0.20(predicted)
Safety Information
MSDS Information
Lipid HTO12 Usage And Synthesis
DescriptionLipid HTO12 is an ionizable cationic lipid (pKa = 6.432) that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo.1 LNPs containing lipid HTO12 and encapsulating adenine base editor mRNA targeting Pcsk9 reduce hepatic Pcsk9 levels in mice at a reduced ionizable lipid/total lipids-to-mRNA ratio than LNPs containing SM-102 (Item No. 33474).WARNING This product is not for human or veterinary use.
References[1] QIUBING CHEN. Minimizing the ratio of ionizable lipid in lipid nanoparticles for in vivo base editing.[J]. National Science Review, 2024, 11 6: nwae135. DOI: 10.1093/nsr/nwae135
Lipid HTO12 Preparation Products And Raw materials
Tag:Lipid HTO12(3047222-45-4) Related Product Information
Lipid U 105 2-Hexadecanol, 1,1′-[[3-[4-[2-[[3-[bis(2-hydroxyhexadecyl)amino]-2-ethoxypropyl](2-hydroxyhexadecyl)amino]ethyl]-1-piperazinyl]-2-ethoxypropyl]imino]bis- Lipid A4 Octanoic acid, 2-butyl-, 1,1'-[[(3-hydroxypropyl)imino]di-9,1-nonanediyl] ester Lipid ND-O1 DSPE-PEG-OH