- L-Leu-OMe.HCl
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2026-09-11
- CAS:7517-19-3
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1T+
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| | Methyl L-leucinate hydrochloride Basic information |
| | Methyl L-leucinate hydrochloride Chemical Properties |
| Melting point | 151-153 °C(lit.) | | alpha | 20 º (c=4.5, MeOH) | | refractive index | 13 ° (C=2, H2O) | | storage temp. | Inert atmosphere,2-8°C | | solubility | H2O: 50 mg/mL, clear, colorless | | form | Crystals or Crystalline Powder | | color | White | | Optical Rotation | [α]22/D +13°, c = 2 in H2O | | Water Solubility | soluble | | Sensitive | Hygroscopic | | BRN | 3595133 | | Major Application | peptide synthesis | | InChI | InChI=1/C7H15NO2.ClH/c1-5(2)4-6(8)7(9)10-3;/h5-6H,4,8H2,1-3H3;1H/t6-;/s3 | | InChIKey | DODCBMODXGJOKD-UZHXKHNSNA-N | | SMILES | [C@H](N)(CC(C)C)C(=O)OC.Cl |&1:0,r| | | CAS DataBase Reference | 7517-19-3(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 22-24/25-36/37/39-27-26 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29224995 | | Storage Class | 11 - Combustible Solids |
| | Methyl L-leucinate hydrochloride Usage And Synthesis |
| Chemical Properties | Crystalline | | Uses | L-Leucine methyl ester is a protected form of L-Leucine (L330110). L-Leucine is an essential amino acid that induces a sharp decrease in blood glucose levels in individuals with idiopathic familial hypoglycemia, but has no known effects on normal, healthy individuals. L-Leucine also acts as an Isoleucine (I820210) antagonist in the rat, causing delays in growth, and is a potential tumour promoter of bladder cancer. | | reaction suitability | reaction type: solution phase peptide synthesis | | Synthesis | Under ice bath conditions, 60 mL of methanol was added to a 100 mL round bottom flask. 4 mL of sulfoxide chloride (SOCl2) was added slowly and dropwise through a constant pressure dropping funnel (with a drying tube fitted at the top), while the resulting off-gas was absorbed using NaOH solution. After stirring the reaction mixture for 1 h, 8 mmol of L-leucine was added and stirring was continued for 30 min at room temperature. Subsequently, the reaction system was warmed up to 66 °C and the reaction was refluxed for 6 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) with an ethanol solution of 2% ninhydrin as the color developer until the raw material spot disappeared. After completion of the reaction, the solvent was removed by distillation under reduced pressure to give L-leucine methyl ester hydrochloride in 100% yield. | | References | [1] Patent: US2014/206741, 2014, A1. Location in patent: Paragraph 0121
[2] Journal of Organic Chemistry, 2003, vol. 68, # 12, p. 5006 - 5008
[3] Synthetic Communications, 2010, vol. 40, # 8, p. 1161 - 1179
[4] Bulletin des Societes Chimiques Belges, 1991, vol. 100, # 1, p. 63 - 77
[5] Chemical Biology and Drug Design, 2012, vol. 79, # 2, p. 216 - 222 |
| | Methyl L-leucinate hydrochloride Preparation Products And Raw materials |
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