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| | 2-(4-morpholinyl)-4-pyridinylamine Basic information |
| Product Name: | 2-(4-morpholinyl)-4-pyridinylamine | | Synonyms: | 2-(4-morpholinyl)-4-pyridinylamine;2-MORPHOLIN-4-YLPYRIDIN-4-AMINE;2-morpholin-4-yl-pyridin-4-ylamine;2-Morpholinopyridin-4-aMine;2-Mrpholinopyridin-4-amine;4-Pyridinamine, 2-(4-morpholinyl)- | | CAS: | 35980-77-9 | | MF: | C9H13N3O | | MW: | 179.22 | | EINECS: | | | Product Categories: | | | Mol File: | 35980-77-9.mol |  |
| | 2-(4-morpholinyl)-4-pyridinylamine Chemical Properties |
| Boiling point | 414.4±45.0 °C(Predicted) | | density | 1.208±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | form | solid | | pka | 9.35±0.10(Predicted) | | Appearance | White to off-white Solid | | InChI | 1S/C9H13N3O/c10-8-1-2-11-9(7-8)12-3-5-13-6-4-12/h1-2,7H,3-6H2,(H2,10,11) | | InChIKey | ZSXQDGMZXKOADT-UHFFFAOYSA-N | | SMILES | Nc1ccnc(c1)N2CCOCC2 |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | WGK 3 | | HS Code | 2934999090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral |
| | 2-(4-morpholinyl)-4-pyridinylamine Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 2-morpholin-4-aminopyridine from morpholine and 2-chloro-4-aminopyridine: 2-chloro-4-aminopyridine (5.0 g, 38.9 mmol) was suspended in aminomethanol (13 mL) and heated in a microwave reactor for 1 hr at 200 °C. Upon completion of the reaction, the mixture was cooled to room temperature and a precipitate was observed to be generated. Ether (45 mL) was added to the mixture, stirred for 10 minutes and filtered. The filter cake was washed with ether and dried to give the target product 2-morpholin-4-amine pyridine (6.61 g, 95% yield). | | References | [1] Patent: WO2008/88881, 2008, A1. Location in patent: Page/Page column 51
[2] Angewandte Chemie - International Edition, 2018, vol. 57, # 34, p. 11035 - 11039
[3] Angew. Chem., 2018, vol. 130, # 34, p. 11201 - 11205,5
[4] Patent: US2005/65151, 2005, A1. Location in patent: Page/Page column 6; 14
[5] Patent: WO2017/93718, 2017, A1. Location in patent: Page/Page column 64 |
| | 2-(4-morpholinyl)-4-pyridinylamine Preparation Products And Raw materials |
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