|
|
| | 5-Amino-2,3,3-trimethyl-3H-indole Basic information |
| Product Name: | 5-Amino-2,3,3-trimethyl-3H-indole | | Synonyms: | 2,3,3-trimethylindol-5-amine;3H-Indol-5-amine, 2,3,3-trimethyl-;2,3,3-TriMethyl-3H-indol-5-aMine;5-Amino-2,3,3-trimethyl-3H-indole | | CAS: | 773-63-7 | | MF: | C11H14N2 | | MW: | 174.24 | | EINECS: | | | Product Categories: | | | Mol File: | 773-63-7.mol |  |
| | 5-Amino-2,3,3-trimethyl-3H-indole Chemical Properties |
| Melting point | 178 °C | | Boiling point | 309.8±42.0 °C(Predicted) | | density | 1.11±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 6.48±0.60(Predicted) | | Appearance | Brown to black Solid |
| | 5-Amino-2,3,3-trimethyl-3H-indole Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 5-amino-2,3,3-trimethyl-3H-indole (product B) from 5-nitro-2,3,3-trimethylindole (product A):
Example of implementation:
A mixture of 6.6 g of Product A, 43.7 g of stannous chloride dihydrate and 215 mL of hydrochloric acid was heated to reflux for 2 hours. Upon completion of the reaction, it was cooled to room temperature and filtered. The collected solid was dissolved in 130 mL of water and neutralized to pH neutral with 20% sodium carbonate solution. The precipitate precipitated was filtered, washed several times with water and subsequently dried under vacuum in the presence of phosphoric acid. 5.4 g of product B was finally obtained in 96% yield. | | References | [1] Patent: US2012/45851, 2012, A1. Location in patent: Page/Page column 14; 18
[2] Organic and Biomolecular Chemistry, 2012, vol. 10, # 4, p. 710 - 715
[3] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1984, vol. 20, # 9, p. 976 - 977
[4] Khimiya Geterotsiklicheskikh Soedinenii, 1984, vol. 20, # 9, p. 1198 - 1199
[5] Journal of Physical Chemistry, 1985, vol. 89, # 18, p. 3941 - 3946 |
| | 5-Amino-2,3,3-trimethyl-3H-indole Preparation Products And Raw materials |
|