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7-Bromo-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one

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7-Bromo-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one manufacturers
7-Bromo-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one Basic information
Product Name:7-Bromo-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
Synonyms:7-broMo-1H-pyrrolo[3,2-d]pyriMidin-4(5H)-one;7-Bromo-1H-pyrrolo[3,2-d]pyrimidin-4(5H);4H-Pyrrolo[3,2-d]pyrimidin-4-one, 7-bromo-3,5-dihydro-;7-bromo-3H,4H,5H-pyrrolo[3,2-d]pyrimidin-4-one;7-Bromo-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
CAS:93587-23-6
MF:C6H4BrN3O
MW:214.02
EINECS:
Product Categories:
Mol File:93587-23-6.mol
7-Bromo-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one Structure
7-Bromo-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one Chemical Properties
storage temp. 2-8°C
AppearanceWhite to off-white Solid
Safety Information
MSDS Information
7-Bromo-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one Usage And Synthesis
Synthesis
1,5-DIHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONE

5655-01-6

7-BROMO-1,5-DIHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONE

93587-23-6

The general procedure for the synthesis of 7-bromo-1,5-dihydro-4H-pyrrolo[3,2-D]pyrimidin-4-one using pyrrolo[3,2-D]pyrimidin-4-one as starting material was as follows: pyrrolo[3,2-D]pyrimidin-4-one (1.70 g, 12.6 mmol) and N-bromosuccinimide (NBS, 2.69 g, 15.1 mmol) were dissolved in N ,N-dimethylformamide (DMF, 100 mL) and the reaction was stirred at room temperature for 18 hours. Upon completion of the reaction, the reaction mixture was diluted with deionized water (50 mL) and the precipitated solid product was collected by filtration. The resulting solid was dried, suspended in methanol (MeOH) and filtered again for purification. Finally, the filtrate was concentrated under reduced pressure to afford the target compound 7-bromo-1,5-dihydro-4H-pyrrolo[3,2-D]pyrimidin-4-one as a beige solid (2.60 g, 97% yield). The product was analyzed by liquid chromatography-mass spectrometry (LCMS) and the molecular weights of the products were confirmed (ES+): 213.9, 215.9 ([M+H]+).

References[1] Patent: US2013/102587, 2013, A1. Location in patent: Paragraph 0271; 0272
7-Bromo-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one Preparation Products And Raw materials
Raw materials1,5-Dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one-->N,N-Dimethylformamide-->N-Bromosuccinimide
Preparation Products7-bromo-4-chloro-5H-pyrrolo[3,2-d]pyrimidine
Tag:7-Bromo-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one(93587-23-6) Related Product Information
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