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7-BROMOPYRIDO[2,3-B]PYRAZINE-2,3(1H,4H)-DIONE

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Products Intro: Product Name:7-BROMOPYRIDO[2,3-B]PYRAZINE-2,3(1H,4H)-DIONE
CAS:168123-82-8
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Products Intro: Product Name:7-Bromopyrido[2,3-b]pyrazine-2,3(1H,4H)-dione
CAS:168123-82-8
Purity:97+% Package:1g;10g;100g;;1kg Remarks:Z-01446
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Products Intro: Product Name:7-bromo-1H,2H,3H,4H-pyrido[2,3-b]pyrazine-2,3-dione
CAS:168123-82-8
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Products Intro: Product Name:7-BROMOPYRIDO[2,3-B]PYRAZINE-2,3(1H,4H)-DIONE
CAS:168123-82-8
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7-BROMOPYRIDO[2,3-B]PYRAZINE-2,3(1H,4H)-DIONE manufacturers
7-BROMOPYRIDO[2,3-B]PYRAZINE-2,3(1H,4H)-DIONE Basic information
Product Name:7-BROMOPYRIDO[2,3-B]PYRAZINE-2,3(1H,4H)-DIONE
Synonyms:7-Bromo-2,3-dioxo-1,4-dihydro-pyrido[2,3-b]pyrazine;7-broMo-1H,2H,3H,4H-pyrido[2,3-b]pyrazine-2,3-dione;7-BROMOPYRIDO[2,3-B]PYRAZINE-2,3(1H,4H)-DIONE;7-bromo-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione;Pyrido[2,3-b]pyrazine-2,3-dione, 7-bromo-1,4-dihydro-;7-BROMOPYRIDO[2,3-B]PYRAZINE-2,3(1H,4H)-DIONE ISO 9001：2015 REACH
CAS:168123-82-8
MF:C7H4BrN3O2
MW:242.03
EINECS:
Product Categories:
Mol File:168123-82-8.mol
7-BROMOPYRIDO[2,3-B]PYRAZINE-2,3(1H,4H)-DIONE Structure
7-BROMOPYRIDO[2,3-B]PYRAZINE-2,3(1H,4H)-DIONE Chemical Properties
density 1.851±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
pka7.95±0.20(Predicted)
AppearanceBrown to gray Solid
Safety Information
MSDS Information
7-BROMOPYRIDO[2,3-B]PYRAZINE-2,3(1H,4H)-DIONE Usage And Synthesis
Synthesis
2,3-Diamino-5-bromopyridine

38875-53-5

Diethyl oxalate

95-92-1

7-BROMOPYRIDO[2,3-B]PYRAZINE-2,3(1H,4H)-DIONE

168123-82-8

General procedure for the synthesis of 7-bromopyrido[2,3-b]pyrazine-2,3(1H,4H)-dione from 2,3-diamino-5-bromopyridine and diethyl oxalate: a mixture of 2,3-diamino-5-bromopyridine (1 mmol) and diethyl oxalate (10 mL) was heated and refluxed for 4 hours. After completion of the reaction, it was cooled to room temperature. The resulting solid was collected by filtration and washed sequentially with ethyl acetate and 95% ethanol. Subsequently, the solid was decolorized using activated charcoal and recrystallized in a solvent mixture of water and DMF or DMSO to afford 7-bromopyrido[2,3-b]pyrazine-2,3(1H,4H)-dione as a white solid (620 mg, 25.6% yield). The product was characterized by IR (KBr) ν 31199, 3138, 3045, 2751, 1715, 1603, 1446, 1389 cm-1; 1H NMR (400 MHz, DMSO-d6) δ 7.55 (1H, d, J = 1.6 Hz, H-6), 8.15 (1H, d, J = 1.6 Hz, H-8); 13C NMR (100 MHz, DMSO-d6) δ 112.36, 123.20, 123.80, 138.46, 141.83, 154.55, 155.58; HRMS-EI C7H4BrN3O2 calculated value [M + H]+ 241.9565, measured value 241.9567.

References[1] European Journal of Medicinal Chemistry, 2016, vol. 117, p. 19 - 32
[2] European Journal of Medicinal Chemistry, 2016, vol. 121, p. 308 - 317
[3] Journal of Medicinal Chemistry, 2018, vol. 61, # 7, p. 2949 - 2961
7-BROMOPYRIDO[2,3-B]PYRAZINE-2,3(1H,4H)-DIONE Preparation Products And Raw materials
Raw materials2,3-Diamino-5-bromopyridine-->Diethyl oxalate
Tag:7-BROMOPYRIDO[2,3-B]PYRAZINE-2,3(1H,4H)-DIONE(168123-82-8) Related Product Information
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