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ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >Pyridine compound >Ethylpyridine >N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine

N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine

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Company Name: ATK CHEMICAL COMPANY LIMITED
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Products Intro: Product Name:JNJ26854165
CAS:881202-45-5
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
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Products Intro: Product Name: N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine
CAS:881202-45-5
Purity:99% Package:5KG;5USD
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Products Intro: Product Name:N-[2-(1H-Indol-3-yl)ethyl]-N-(4-pyridinyl)-1,4-benzenediamine
CAS:881202-45-5
Purity:0.99 Package:5KG;1KG
Company Name: BOC Sciences
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Products Intro: Product Name:Serdemetan
CAS:881202-45-5
Purity:>98% Package:100 mg Remarks:Reach out to us for more information about custom solutions.
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Products Intro: Product Name:N1-(2-(1H-Indol-3-yl)ethyl)-N4-(pyridin-4-yl)benzene-1,4-diamine
CAS:881202-45-5
Purity:97+% Package:1g;10g;100g;;1kg Remarks:Z-63032

N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine manufacturers

  • Serdemetan
  • Serdemetan pictures
  • $39.00 / 2mg
  • 2026-01-20
  • CAS:881202-45-5
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  • Purity: 97.13%
  • Supply Ability: 10g
N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine Basic information
Product Name:N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine
Synonyms:CS-389;JNJ 26854165; JNJ26854165; JNJ-26854165;JNJ 26854165;SerdeMetan;JNJ-26854165 (SerdeMetan);JNJ 26854165 N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine;N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine JNJ 26854165;JNJ-26854165, >=98%
CAS:881202-45-5
MF:C21H20N4
MW:328.41
EINECS:200-256-5
Product Categories:Inhibitors;Inhibitor
Mol File:881202-45-5.mol
N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine Structure
N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine Chemical Properties
storage temp. Store at -20°C
solubility insoluble in EtOH; insoluble in H2O; ≥14.8 mg/mL in DMSO
form solid
color Light brown to brown
InChIInChI=1S/C21H20N4/c1-2-4-21-20(3-1)16(15-24-21)9-14-23-17-5-7-18(8-6-17)25-19-10-12-22-13-11-19/h1-8,10-13,15,23-24H,9,14H2,(H,22,25)
InChIKeyCEGSUKYESLWKJP-UHFFFAOYSA-N
SMILESC1(NCCC2C3=C(NC=2)C=CC=C3)=CC=C(NC2C=CN=CC=2)C=C1
Safety Information
WGK Germany WGK 3
HS Code 29339900
Storage Class11 - Combustible Solids
MSDS Information
N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine Usage And Synthesis
UsesJNJ 26854165 is a p53 activator and HDM2 ubiquitin ligase (MDM2) inhibitor.
Biological Activityjnj-26854165, also named as serdemetan, is originally developed as an activator of p53, is now regarded as a novel oral human double minute-2 (hdm-2) ubiquitin ligase antagonist. it can increase the level of hdm-2 client proteins, such as p53, by inhibiting the association of hdm-2-client protein complex with the proteosome. it is demonstrated potent anti-proliferative and apoptosis-inducing activity of jnj-26854165 in a broad range of p53 wild type and mutant tumor models. in vivo, jnj-26854165 may induce important differences in efs distribution when comparing to control in 18 of 37 solid tumors and in 5 of 7 of the evaluable all xenografts.j. tabernero, l. dirix, p. schoffski, a. cervantes, j. capdevila, j. baselga, l. van beijsterveldt, h. winkler, s. kraljevic and s. h. zhuang. phase i pharmacokinetic (pk) and pharmacodynamic (pd) study of hdm-2 antagonist jnj-26854165 in patients with advanced refractory solid tumors. journal of clinical oncology (meeting abstracts) may 2009 vol. 27 no. 15s 3514malcolm a. smith, richard gorlick, e. anders kolb, richard lock, hernan carol, john m. maris, stephen t. keir, christopher l. morton, c. patrick reynolds, min h. kang, janine arts, tarig bashir, michel janicot, raushan t. kurmasheva, peter j. houghton. initial testing of jnj-26854165 (serdemetan) by the pediatric preclinical testing program. pediatric blood & cancer. volume 59, issue 2, pages 329–332, august 2012.
targetHDM2
N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine Preparation Products And Raw materials
Tag:N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine(881202-45-5) Related Product Information
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