ChemicalBook > Product Catalog >Biochemical Engineering >Biochemical Reagents >Agonist Inhibitors >(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate

(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate

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(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate Suppliers list
Company Name: CONIER CHEM AND PHARMA LIMITED
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Products Intro: Product Name:sumanirole maleate
CAS:179386-44-8
Purity:0.99 Package:1kg
Company Name: Career Henan Chemica Co
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Products Intro: Product Name:Sumanirole maleate
CAS:179386-44-8
Purity:95%-99% crystal Liu Package:1KG;0.01USD
Company Name: Shanghai Acmec Biochemical Technology Co., Ltd.
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Products Intro: Product Name:Sumanirole maleate
CAS:179386-44-8
Purity:98% Package:5mg, 50mg, 25mg, 100mg
Company Name: Aladdin Scientific
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Products Intro: Product Name:Sumanirole maleate
CAS:179386-44-8
Purity:98% Package:$81.9/5mg;$147.9/10mg;$303.9/25mg;$576.9/50mg;$1000.9/100mg;Bulk package Remarks:98%
Company Name: SHANGHAI KEAN TECHNOLOGY CO., LTD.
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Products Intro: Product Name:Sumanirole maleate
CAS:179386-44-8
Purity:0.99 Package:100g;1kg;5KG;1KG
(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate Basic information
Product Name:(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate
Synonyms:(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate;PNU 95666;Sumanirole maleate;U 95666E(Sumanirole maleate);U95666E;PNU 95666E;(5R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one maleate;(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one maleate
CAS:179386-44-8
MF:C15H17N3O5
MW:319.32
EINECS:604-604-1
Product Categories:
Mol File:179386-44-8.mol
(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate Structure
(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate Chemical Properties
Melting point 200-208°C (dec.)
storage temp. -20°C
solubility H2O: soluble10mg/mL, clear
form powder
color white to beige
Optical Rotation[α]/D -22 to -32°, c = 1 in H2O
Water Solubility H2O: 10mg/mL, clear
InChI1S/C11H13N3O.C4H4O4/c1-12-8-5-7-3-2-4-9-10(7)14(6-8)11(15)13-9;5-3(6)1-2-4(7)8/h2-4,8,12H,5-6H2,1H3,(H,13,15);1-2H,(H,5,6)(H,7,8)/b;2-1-/t8-;/m1./s1
InChIKeyVOJRMYBBPKNLLI-ORHWHDKWSA-N
SMILESO=C1N(C[C@H](NC)C2)C3=C2C=CC=C3N1.O=C(O)/C=C\C(O)=O
Safety Information
WGK Germany 3
Storage Class11 - Combustible Solids
MSDS Information
(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate Usage And Synthesis
UsesSumanirole is a high affinity D2 receptor agonist (EC50 values are between 17 and 75 nM in cell-based assays). Sumanirole displays >200-fold selectivity for the D2 receptor against other dopamine receptor subtypes (Ki values are 9.0, 1940, >2190 and >7140 for D2, D3, D4 and D1 receptors respectively). Sumanirole exhibits antiParkinsonian activity similar to Ropinirole (R641000).
Biochem/physiol ActionsSumanirole is a highly selective and potent dopamine D2 receptor agonist that decreased plasma prolactin levels and depressed dopamine neuron firing rates in the substantia nigra pars compacta. Sumanirole potently stimulates locomotor activity in in animal models of Parkinson′s disease.
IC 50D2 Receptor
storageStore at -20°C
(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate Preparation Products And Raw materials
Tag:(R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate(179386-44-8) Related Product Information
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