2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione manufacturers
- ML-SA1
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- $47.00
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2026-04-22
- CAS:332382-54-4
- Purity: 99.34%
- Supply Ability: 10g
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| | 2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione Basic information |
| Product Name: | 2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione | | Synonyms: | 2-[2-oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1-yl)ethyl]isoindole-1,3-dione;TRPML Agonist, ML-SA1 - CAS 332382-54-4 - Calbiochem;2-[2-(3,4-Dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione;2-[2-oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1-yl)ethyl]isoindoline-1,3-dione;BAS 01520422;BIM-0009825.P001;CBMicro_009667;ChemDiv1_023217 | | CAS: | 332382-54-4 | | MF: | C22H22N2O3 | | MW: | 362.42 | | EINECS: | | | Product Categories: | | | Mol File: | 332382-54-4.mol | ![2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione Structure](CAS/GIF/332382-54-4.gif) |
| | 2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione Chemical Properties |
| Boiling point | 546.7±43.0 °C(Predicted) | | density | 1.226±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: soluble5mg/mL, clear (warmed) | | form | powder | | pka | 1.16±0.60(Predicted) | | color | white to beige | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. | | InChI | 1S/C22H22N2O3/c1-14-12-22(2,3)24(18-11-7-6-8-15(14)18)19(25)13-23-20(26)16-9-4-5-10-17(16)21(23)27/h4-11,14H,12-13H2,1-3H3 | | InChIKey | KDDHBJICVBONAX-UHFFFAOYSA-N | | SMILES | N3(C(=O)c4c(cccc4)C3=O)CC(=O)N1C(CC(c2c1cccc2)C)(C)C |
| Hazard Codes | T | | Risk Statements | 25-50/53 | | Safety Statements | 60-61 | | RIDADR | UN 2811 6.1 / PGIII | | WGK Germany | 3 | | HazardClass | IRRITANT | | Storage Class | 11 - Combustible Solids |
| | 2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione Usage And Synthesis |
| Description | ML-SA1 (332382-54-4) is aTRPML 1,2 and 3 channel activator.1Does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels.2ML-SA1 robustly activates whole cell TRPML1-4A and whole-endolysosome TRPML1 and is comparable (10 μM) to the effect of the endogenous TRPML agonist, PI(3,5)P2(1 μM).2Thus it is a useful chemical tool for studying the functions of TRPMLs. It induces TRPML-mediated Ca2+release from lysosomes which corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages.2,3Reduces intralysosomal Ca2+level rescuing abnormal lysosomal storage in FIG4-deficient cells.4 | | Uses | ML-SA1 has been used as a transient receptor potential cation channel mucolipin 1 (TRPML1/ML1) agonist. | | Biochem/physiol Actions | ML-SA1 is a potent and selective cell permeable agonist of lysosomal mucolipin transient receptor potential channels (TRPML) 1, 2, 3 that significantly increases [Ca2+]cyt in HEK293 cells stably- or transiently-expressing mutant TRPML1 channels ML1-4A. | | storage | Store at +4°C | | References | [1] CHRISTIAN GRIMM. Small molecule activators of TRPML3.[J]. Chemistry & biology, 2010: 135-148. DOI:10.1016/j.chembiol.2009.12.016
[2] DONGBIAO SHEN. Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release.[J]. Nature Communications, 2012: 731. DOI:10.1038/ncomms1735
[3] WEISS N. Cross-talk between TRPML1 channel, lipids and lysosomal storage diseases.[J]. Communicative and Integrative Biology, 2012, 5 2: 111-113. DOI:10.4161/cib.20373
[4] JIANLONG ZOU. Reactivation of Lysosomal Ca2+ Efflux Rescues Abnormal Lysosomal Storage in FIG4-Deficient Cells.[J]. Journal of Neuroscience, 2015, 35 17: 6801-6812. DOI:10.1523/jneurosci.4442-14.2015 |
| | 2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione Preparation Products And Raw materials |
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