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DG 051 (HCl salt)

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CAS:929915-58-2
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CAS:929915-58-2
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CAS:929915-58-2
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Products Intro: Product Name:DG 051 (HCl salt)
CAS:929915-58-2
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Products Intro: Product Name:4-((S)-2-((4-(4-chlorophenoxy)phenoxy)Methyl)pyrrolidin-1-yl)butanoic acid hydrochloride
CAS:929915-58-2
Purity:95% HPLC Package:1g,5g,10g,25g,50g,100g

DG 051 (HCl salt) manufacturers

  • DG 051 (HCl salt)
  • DG 051 (HCl salt) pictures
  • $1.00
  • 2019-07-06
  • CAS:929915-58-2
  • Min. Order: 1KG
  • Purity: 96%
  • Supply Ability: 500kg
DG 051 (HCl salt) Basic information
Product Name:DG 051 (HCl salt)
Synonyms:DG 051 (HCl salt);4-((S)-2-((4-(4-chlorophenoxy)phenoxy)Methyl)pyrrolidin-1-yl)butanoic acid hydrochloride;DG051;(2S)-2-[[4-(4-Chlorophenoxy)phenoxy]methyl]-1-pyrrolidinebutanoic Acid Hydrochloride;DG051 (DG-051;DG051,Aminopeptidase,inhibit,DG 051,Inhibitor,DG-051;DG051, 10 mM in DMSO;(S)-4-(2-((4-(4-Chlorophenoxy)phenoxy)methyl)pyrrolidin-1-yl)butanoic acid hydrochloride
CAS:929915-58-2
MF:C21H25Cl2NO4
MW:426.3335
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Mol File:929915-58-2.mol
DG 051 (HCl salt) Structure
DG 051 (HCl salt) Chemical Properties
storage temp. Store at -20°C
solubility DMF: 20 mg/ml; DMSO: 12.5 mg/ml; Ethanol: 12.5 mg/ml; PBS (pH 7.2): 2 mg/ml
form Solid
color White to light yellow
InChIInChI=1/C21H24ClNO4.ClH/c22-16-5-7-19(8-6-16)27-20-11-9-18(10-12-20)26-15-17-3-1-13-23(17)14-2-4-21(24)25;/h5-12,17H,1-4,13-15H2,(H,24,25);1H/t17-;/s3
InChIKeyUCPVOTSNNAVKNE-VOPAOICTNA-N
SMILESC(O)(=O)CCCN1CCC[C@H]1COC1=CC=C(OC2=CC=C(Cl)C=C2)C=C1.Cl |&1:10,r|
Safety Information
MSDS Information
DG 051 (HCl salt) Usage And Synthesis
DescriptionDG-051 is a potent, orally bioavailable leukotriene A4 hydrolase (LTA4H) inhibitor (Kd = 25 nM; IC50 = 47 nM), the enzyme that catalyzes the rate-determining step in the synthesis of LTB4 . However, it also inhibits the aminopeptidase activity of LTA4H with IC50 values of 72 and 150 nM when tested using the substrates L-alanine p-nitroanaline and prolyl-glycyl-proline peptide (PGP; ), respectively, potentially leading to PGP accumulation in vivo. DG-051 does not show any inhibitory activity against a panel of more than 50 additional aminopeptidases, ion channels, or HERG.
Uses(2S)-2-[[4-(4-Chlorophenoxy)phenoxy]methyl]-1-pyrrolidinebutanoic Acid Hydrochloride is a potent inhibitor leukotriene A4 hydrolase (LTA4H), which is a therapeutic target for developing treatments for cardiovascular diseases and cancers.
References[1] VINCENT SANDANAYAKA. Discovery of 4-[(2S)-2-{[4-(4-Chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic Acid (DG-051) as a Novel Leukotriene A4 Hydrolase Inhibitor of Leukotriene B4 Biosynthesis[J]. Journal of Medicinal Chemistry, 2009, 53 2: 573-585. DOI: 10.1021/jm900838g
[2] CAROLINE M LOW. The development of novel LTA4H modulators to selectively target LTB4 generation.[J]. Scientific Reports, 2017: 44449. DOI: 10.1038/srep44449
DG 051 (HCl salt) Preparation Products And Raw materials
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