| Company Name: |
ChemeGen |
| Tel: |
18818260767 |
| Email: |
2625930290@qq.com |
AMbroxol-d5 HCl manufacturers
- Ambroxol-D5
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- $1980.00
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2026-04-22
- CAS:1246818-80-3
- Purity:
- Supply Ability: 10g
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| | AMbroxol-d5 HCl Basic information |
| | AMbroxol-d5 HCl Chemical Properties |
| storage temp. | -20°C | | solubility | Acetonitrile: soluble,DMSO: soluble,Methanol: soluble | | Water Solubility | Water: soluble |
| | AMbroxol-d5 HCl Usage And Synthesis |
| Biological Activity | Ambroxol-d5 is intended for use as an internal standard for the quantification of ambroxol by GC- or LC-MS. Ambroxol is an expectorant and active metabolite of bromhexine.1 It decreases short-circuit currents in electrically stimulated isolated canine tracheal epithelial cells when applied submucosally (IC50 = 60 nM).2 Ambroxol (100 μM) decreases IL-13-induced production of mucin 5AC (MUC5AC) in primary human airway epithelial cells and inhibits IL-13-induced decreases in the mucociliary transport rate of endogenous particles in the same cells.3 Ambroxol increases phenol red secretion, a marker of expectorant activity, in mice when administered at doses of 30, 60, or 120 mg/kg.4 Formulations containing ambroxol have been used in the treatment of acute or chronic respiratory conditions. | | References | 1.Malerba, M., and Ragnoli, B.Ambroxol in the 21st century: Pharmacological and clinical updateExpert Opin. Drug Metab. Toxicol.4(8)1119-1129(2008)
2.Tamaoki, J., Chiyotani, A., Yamauchi, F., et al.Ambroxol inhibits Na+ absorption by canine airway epithelial cells in cultureJ. Pharm. Pharmacol.43(12)841-843(1991)
3.Seagrave, J., Albrecht, H.H., Hill, D.B., et al.Effects of guaifenesin, N-acetylcysteine, and ambroxol on MUC5AC and mucociliary transport in primary differentiated human tracheal-bronchial cellsRespir. Res.13(1)98(2012)
4.Menezes, P.M.N., Brito, M.C., Sousa de Sá, P.G., et al.Analytical and pharmacological validation of the quantification of phenol red in a mouse model: An optimized method to evaluate expectorant drugsJ. Pharmacol. Toxicol. Methods98106586(2019) |
| | AMbroxol-d5 HCl Preparation Products And Raw materials |
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