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| | Etilefrine hydrochloride Basic information |
| Product Name: | Etilefrine hydrochloride | | Synonyms: | alpha-((ethylamino)methyl)-m-hydroxybenzylalcoholhydrochloride;3-[2-(ETHYLAMINO)-1-HYDROXYETHYL]PHENOL HYDROCHLORIDE;2-ETHYLAMINO-1-(3-HYDROXYPHENYL)ETHANOL HYDROCHLORIDE;LABOTEST-BB LT00244796;Etilefrina;ETILEFRIN HYDROCHLORIDE 98+%;(+-)-Ethylphenylephrine hydrochloride;dl-n-ethylnorphenylephrine hydrochloride | | CAS: | 943-17-9 | | MF: | C10H15NO2.ClH | | MW: | 217.69 | | EINECS: | 213-398-8 | | Product Categories: | | | Mol File: | 943-17-9.mol |  |
| | Etilefrine hydrochloride Chemical Properties |
| Melting point | 122 °C | | storage temp. | -20°C | | solubility | Freely soluble in water, soluble in ethanol (96 per cent), practically insoluble in methylene chloride | | form | Solid | | color | White to off-white | | InChI | InChI=1S/C10H15NO2.ClH/c1-2-11-7-10(13)8-4-3-5-9(12)6-8;/h3-6,10-13H,2,7H2,1H3;1H | | InChIKey | KTNROWWHOBZQGK-UHFFFAOYSA-N | | SMILES | Cl.OC1=CC=CC(=C1)C(O)CNCC |
| RIDADR | UN 2811 6.1 / PGIII | | RTECS | DO5618000 | | HS Code | 2922290090 |
| | Etilefrine hydrochloride Usage And Synthesis |
| Chemical Properties | White or almost white, crystalline powder or colourless crystals. | | Originator | Circupon,Troponwerke,W. Germany | | Uses | Adrenoceptor agonist. | | Definition | ChEBI: Etilefrine hydrochloride (TN) is a member of phenols. | | Manufacturing Process | 30 parts of 1-(3'-hydroxyphenyl)-2-(N-benzylaminomethyl)-ethan-1-one are
mixed with 100 parts of pyridine and 30 parts of pivalic anhydride and
dissolved while warming. After heating for 1 hour under reflux, the acylation
is complete. After concentrating the reaction solution, the product is
precipitated from acetone/ether. Yield: 96.4% of 1-(3'-pivaloyloxyphenyl)-2-
(N-benzylaminomethyl)-ethan-1-one.
3 parts of palladium/charcoal (10% strength) are prehydrogenated in water,
thereafter 10 parts of 1-(3'-pivaloyloxyphenyl)-2-(N-benzylaminoethyl)-ethan-
1-one, dissolved in a 10-fold amount of water, are added dropwise at room
temperature and hydrogenation is carried out until 1 mol of hydrogen has
been taken up. After filtering off the catalyst, a further 3 parts of
palladium/charcoal are added and hydrogenation is carried out until a further
mol of hydrogen has been taken up. The catalyst is separated off and after
removal of the solvent the hydrogenation product is reprecipitated from
acetone/petroleum ether and from methanol/ether until it is pure according to
thin layer chromatography. Yield: 38.8% of 1-(3'-pivaloyloxyphenyl)-2-
ethylaminoethanol-1 hydroxide, melting point 208°C to 209°C. | | Therapeutic Function | Tranquilizer |
| | Etilefrine hydrochloride Preparation Products And Raw materials |
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