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| | AMINOGUANIDINE HYDROCHLORIDE Basic information | | Uses |
| | AMINOGUANIDINE HYDROCHLORIDE Chemical Properties |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | RTECS | ME8430000 | | F | 10-21 | | HS Code | 29280000 |
| | AMINOGUANIDINE HYDROCHLORIDE Usage And Synthesis |
| Uses | Aminoguanidine Hydrochloride is used in the synthetic preparation of highly selective and potent G-protein-coupled receptor kinase 2 (GRK2) inhibitor for potential treatment of heart failure. | | Description | Aminoguanidine is equipotent to L-NMMA and L-NNA as an inhibitor of iNOS. The IC50 values for inhibition of mouse iNOS and rat nNOS are 5.4 and 160 μM, respectively. Aminoguanidine also inhibits induction of iNOS protein expression by endotoxin in rat macrophages. | | Chemical Properties | white to off-white crystals | | Uses | antitussive | | Uses | a-Glucosidase inhibitor; hydroxyethyl derivative of 1-deoxynojirimycin | | Uses | Aminoguanidine hydrochloride may be employed as nitric oxide synthase (NOS) inhibitor to investigate its effect on the reduction of alveolar bone loss in ligature induced periodontitis in rats. It may be used in the synthesis of 5-guanylhydrazone derivatives, having antibacterial activity against antibacterial activity against both Escherichia coli and Staphylococcus aureus. | | General Description | Aminoguanidine hydrochloride has been reported in a study as inhibitor of animal nitric oxide (NO)-synthase. Crystal structure of aminoguanidine hydrochloride has been investigated by Fourier and least squares method. Its crystals were monoclinic and the guanidine part of the aminoguanidinium ion is planar. | | Flammability and Explosibility | Not classified | | Biochem/physiol Actions | Inhibits both constitutive and inducible nitric oxide synthetase. |
| | AMINOGUANIDINE HYDROCHLORIDE Preparation Products And Raw materials |
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