429653-73-6
| 中文名称 | 429653-73-6 |
|---|---|
| 中文同义词 | G蛋白偶联RHO GEFS抑制剂(Y16);化合物Y16;4-(3-((3-甲基苄基)氧基)亚苄基)-1-苯基吡唑烷-3,5-二酮;化合物Y16,10 MM DMSO 溶液;Y16 (Rho GEFs inhibitor Y16);信号通路;信号通路 |
| 英文名称 | Y16 |
| 英文同义词 | Y16;4-[[3-[(3-Methylphenyl)methoxy]phenyl]methylene]-1-phenyl-3,5-pyrazolidinedione;Y16, >98%;Y16, 429653-73-6;3,5-Pyrazolidinedione, 4-[[3-[(3-methylphenyl)methoxy]phenyl]methylene]-1-phenyl-;Inhibitor,inhibit,Y-16,Y 16,Ras,Y16;4-(3-((3-Methylbenzyl)oxy)benzylidene)-1-phenylpyrazolidine-3,5-dione;Y16, 10 mM in DMSO |
| CAS号 | 429653-73-6 |
| 分子式 | C24H20N2O3 |
| 分子量 | 384.43 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂 |
| Mol文件 | 429653-73-6.mol |
| 结构式 |  |
429653-73-6 性质
| 密度 | 1.273±0.06 g/cm3(Predicted) |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | DMSO：可溶5mg/mL，澄清（加热） |
| 酸度系数(pKa) | 8.84±0.20(Predicted) |
| 形态 | 粉末 |
| 颜色 | 淡黄色至深橙色 |
| InChI | 1S/C24H20N2O3/c1-17-7-5-9-19(13-17)16-29-21-12-6-8-18(14-21)15-22-23(27)25-26(24(22)28)20-10-3-2-4-11-20/h2-15H,16H2,1H3,(H,25,27) |
| InChIKey | ITMLWGWTDWJSRZ-UHFFFAOYSA-N |
| SMILES | N2(NC(=O)C(=Cc3cc(ccc3)OCc4cc(ccc4)C)C2=O)c1ccccc1 |
Y16是G蛋白偶联Rho GEFs抑制剂。它能阻止LARG和Rho的结合，Kd值为80 nM。
| Target | Value |
|
RhoGEFs
() |
Y16 (10-30 μΜ; 24 hours; NIH 3T3 cells) could inhibit RhoA-GTP formation induced by serum dose dependently and is specific for RhoA.
Y16 (10-30 μΜ; 24 hours; NIH 3T3 cells) efficiently inhibits serum or SDF-1α-induced phospho-MLC and phospho-FAK formation, which are downstream of RhoA.
Cell Viability Assay
| Cell Line: | NIH 3T3 cells |
| Concentration: | 10 μΜ, 30 μΜ |
| Incubation Time: | 24 hours |
| Result: | Inhibited RhoA-GTP formation induced by serum dose dependently and was specific for RhoA. |
Western Blot Analysis
| Cell Line: | NIH 3T3 cells |
| Concentration: | 10 μΜ, 30 μΜ |
| Incubation Time: | 24 hours |
| Result: | Inhibited serum or SDF-1α-induced phospho-MLC and phospho-FAK formation, which were downstream of RhoA. |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/03/03 | S6752 | 429653-73-6 Y16 | 429653-73-6 | 5mg | 794.64元 |
| 2025/12/22 | HY-12649 | Y16 | 429653-73-6 | 1 mg | 320元 |