RS 102221 hydrochloride

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Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
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Company Name: Jinan ponder chemical co. LTD  
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RS 102221 hydrochloride Basic information
Product Name:RS 102221 hydrochloride
Synonyms:8-[5-(2,4-Dimethoxy-5-(4-trifluoromethylphenylsulfonamido)phenyl-5-oxopentyl]-1,3,8-triazaspiro[4.5]decane-2,4-dionehy;RS102221HCl;8-[5-(2,4-Dimethoxy-5-(4-trifluoromethylphenylsulfonamido)phenyl-5-oxopentyl]-1,3,8-triazaspiro[4.;8-[5-(2,4-Dimethoxy-5-(4-Trifluoromethylphenylsulphonamido)Phenyl-5-Oxopentyl)]-1,3,8-Triazaspiro[4.5]Decane-2,4-Dione Hydrochloride;8-[5-(2,4-DIMETHOXY-5-(4-TRIFLUOROMETHYLPHENYLSULPHONAMIDO)PHENYL-5-OXOPENTYL)]-1,3,8-TRIAZASPIRO[4.5]DECANE-2,4-DIONE HYDROCHLORIDE;N-[5-[5-(2,4-Dioxo-1,3,8-triazaspiro[4.5]dec-8-yl)-1-oxopentyl]-2,4-dimethoxyphenyl]-4-(trifluoromethyl)benzenesulfonamide;RS 102221;4-dione hydrochloride hydrate
CAS:185376-97-0
MF:C27H31F3N4O7S
MW:612.62
EINECS:
Product Categories:
Mol File:185376-97-0.mol
RS 102221 hydrochloride Structure
RS 102221 hydrochloride Chemical Properties
density 1.45
storage temp. Store at RT
solubility DMSO: ≥20mg/mL
form powder
color white
InChIKeyIGACJTZTAQBWKN-UHFFFAOYSA-N
SMILESO.Cl.COc1cc(OC)c(cc1NS(=O)(=O)c2ccc(cc2)C(F)(F)F)C(=O)CCCCN3CCC4(CC3)NC(=O)NC4=O
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26
WGK Germany 3
Storage Class11 - Combustible Solids
Hazard ClassificationsEye Irrit. 2
Skin Irrit. 2
STOT SE 3
MSDS Information
RS 102221 hydrochloride Usage And Synthesis
UsesRS 102221 Hydrochloride is a selective 5-HT2C receptor antagonist.
DefinitionChEBI: N-[5-[5-(2,4-dioxo-1,3,8-triazaspiro[4.5]decan-8-yl)-1-oxopentyl]-2,4-dimethoxyphenyl]-4-(trifluoromethyl)benzenesulfonamide is an aromatic ketone.
Biological ActivityPotent and selective 5-HT 2C antagonist (pK i = 8.7). Displays ~ 100-fold selectivity over the 5-HT 2A and 5-HT 2B subtypes and is > 100-fold selective over other 5-HT receptors, a- and b-adrenergic and muscarinic ACh receptors.
RS 102221 hydrochloride Preparation Products And Raw materials
Tag:RS 102221 hydrochloride(185376-97-0) Related Product Information
5-Methanesulphonamido-2-hydroxyacetophenone 1,3,8-Triaza-spiro[4.5]decane-2,4-dione RS 102221 hydrochloride N-(5-Acetyl-2-hydroxy-phenyl)-methanesulfonamide Puerarin DL-4-Chlorophenylalanine methyl ester hydrochloride