AZ6102 manufacturers
- AZ6102
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- $37.00
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2026-07-27
- CAS:1645286-75-4
- Purity: 99.91%
- Supply Ability: 10g
- AZ6102
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2024-03-28
- CAS:1645286-75-4
- Min. Order: 25kg
- Purity: 98%-99%
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| Product Name: | AZ6102 | | Synonyms: | AZ-6102;AZ6102;AZ 6102;CS-2332;AZ6102;rel-2-[4-[6-[(3R,5S)-3,5-Dimethyl-1-piperazinyl]-4-methyl-3-pyridinyl]phenyl]-3,7-dihydro-7-methyl-4H-pyrrolo[2,3-d]pyrimidin-4-one;4H-Pyrrolo[2,3-d]pyrimidin-4-one, 2-[4-[6-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-4-methyl-3-pyridinyl]phenyl]-3,7-dihydro-7-methyl-, rel-;AZ6102 >=98% (HPLC);2-(4-(6-((3S,5R)-3,5-Dimethylpiperazin-1-yl)-4-methylpyridin-3-yl)phenyl)-7-methyl-3Hpyrrolo[2,3-d]pyrimidin-4(7H)-one;AZ 6102,PARP,AZ-6102,Inhibitor,poly ADP ribose polymerase,inhibit,AZ6102 | | CAS: | 1645286-75-4 | | MF: | C25H28N6O | | MW: | 428.53 | | EINECS: | | | Product Categories: | | | Mol File: | 1645286-75-4.mol |  |
| | AZ6102 Chemical Properties |
| Boiling point | 657.6±65.0 °C(Predicted) | | density | 1.31±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | crystalline solid | | pka | 8.70±0.60(Predicted) | | color | Light yellow to yellow | | SMILES | CN1C=CC2=C1N=C(C3=CC=C(C4=CN=C(N5C[C@H](C)N[C@H](C)C5)C=C4C)C=C3)NC2=O |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | AZ6102 Usage And Synthesis |
| Uses | AZ 6102 is a a potent TNKS1/2 inhibitor that has 100-fold selectivity against other poly(ADP-ribose) polymerase (PARP) family enzymes. | | Biological Activity | az6102 is a tnks1/2 inhibitor.inhibition of the poly(adp-ribose) polymerase (parp) catalytic domain of the tankyrases (tnks1 and tnks2) is reported to inhibit the wnt pathway by increasing stabilization of axin. the canonical wnt pathway plays a critical role in adult tissue homeostasis, embryonic development, as well as cancer. | | in vitro | az6102 was identified as a potent tnks1/2 inhibitor with 100-fold selectivity against other parp family enzymes including parps 1, 2, and 6. in addition, az6102 showed a 5 nm ic50 against wnt pathway in dld-1 cells [1]. | | in vivo | in animal study, az6102 was intravenously dosed to nude mice at 25 mg/kg, and the results showed that az6102 had a clearance of 24 ml/min·kg and a half-life of 4 h. the bioavailability of az6102 in mouse and rat was only moderate at 12% and 18%, respectively. in addition, az6102 was used as an intravenous probe compound to evaluate the in vivo effects of tnks1/2 inhibition on normal tissue and tumor xenografts, however, the results of such experiments have not be released so far [1]. | | IC 50 | 1 and 3 nm for tnks2 and tnks1, respectively | | storage | Store at -20°C | | references | [1] j. w. johannes, l. almeida, b. barlaam,et al.pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathways inhibitors suitable for in vivopharmacology. acs med. chem. lett. 6, 254-259 (2015). |
| | AZ6102 Preparation Products And Raw materials |
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