|
|
| | 4-(DIFLUOROMETHOXY)ACETOPHENONE Basic information |
| Product Name: | 4-(DIFLUOROMETHOXY)ACETOPHENONE | | Synonyms: | AKOS B016264;AKOS BBS-00000545;4-(DIFLUOROMETHOXY)ACETOPHENONE;1-(4-DIFLUOROMETHOXY-PHENYL)-ETHANONE;ART-CHEM-BB B016264;1-[4-(difluoromethoxy)phenyl]ethan-1-one;4'-(Difluoromethoxy)acetophenone 98%;4'-(Difluoromethoxy)acetophenone98% | | CAS: | 83882-67-1 | | MF: | C9H8F2O2 | | MW: | 186.16 | | EINECS: | 281-174-7 | | Product Categories: | | | Mol File: | 83882-67-1.mol |  |
| | 4-(DIFLUOROMETHOXY)ACETOPHENONE Chemical Properties |
| Melting point | 18-19°C | | Boiling point | 70-72°C 0,5mm | | density | 1.191±0.06 g/cm3(Predicted) | | refractive index | 1.4930 to 1.4970 | | storage temp. | Sealed in dry,Room Temperature | | form | clear liquid | | color | Light orange to Yellow to Green | | λmax | 252nm(EtOH)(lit.) | | CAS DataBase Reference | 83882-67-1(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | Hazard Note | Irritant | | HS Code | 2914790090 |
| | 4-(DIFLUOROMETHOXY)ACETOPHENONE Usage And Synthesis |
| Chemical Reactivity | 4-(DIFLUOROMETHOXY)ACETOPHENONE is a chemical compound that contains the difluoromethoxy group. It has been shown to be a nitrogen-containing heterocycle, which makes it an important part of many pyridine derivatives. The cyclic molecule is also known as 1,2-difluoroethanone. | | Synthesis | To a stirred solution of 4-hydroxyacetophenone (5.0 g, 36.76 mmol) in N,N-dimethylformamide (DMF, 50 mL) was added sodium 2-chloro-2,2-difluoroacetate (6.2 g, 40.44 mmol) followed by sodium hydroxide (NaOH, 1.76 g, 44.11 mmol). The reaction mixture was stirred at 100 °C for 14 hours. After completion of the reaction, the mixture was diluted with cold water and the product was extracted with ethyl acetate (EtOAc). The organic layers were combined, dried with anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using a 20-30% ethyl acetate/hexane solvent mixture to afford the target compound 1-(4-difluoromethoxyphenyl)ethanone (3.5 g, 51.0% yield) as a colorless liquid.1H NMR (400 MHz, DMSO-d6): δ 8.05-8.01 (m, 2H), 7.59-7.22 (m 3H), 2.50 (s, 3H); LC-MS: m/z 187.0 [M+H]+. | | References | [1] Patent: WO2018/165520, 2018, A1. Location in patent: Page/Page column 215-216 |
| | 4-(DIFLUOROMETHOXY)ACETOPHENONE Preparation Products And Raw materials |
|