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| | Sodium chlorodifluoroacetate Basic information |
| | Sodium chlorodifluoroacetate Chemical Properties |
| Melting point | 196-198 °C (lit.) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | Soluble in dimethoxyethane, diglyme (0.60 g mL-1), triglyme, dimethyl formamide. | | form | Powder | | color | White to off-white | | BRN | 4162363 | | InChI | InChI=1S/C2HClF2O2.Na.H/c3-2(4,5)1(6)7;;/h(H,6,7);; | | InChIKey | MRTAVLDNYYEJHK-UHFFFAOYSA-M | | SMILES | C(F)(F)(Cl)C(=O)O.[NaH] | | CAS DataBase Reference | 1895-39-2(CAS DataBase Reference) | | EPA Substance Registry System | Acetic acid, chlorodifluoro-, sodium salt (1895-39-2) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39-24/25-36/37/39 | | WGK Germany | 3 | | Hazard Note | Irritant | | TSCA | TSCA listed | | HazardClass | IRRITANT, HYGROSCOPIC | | HS Code | 29159080 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | Sodium chlorodifluoroacetate Usage And Synthesis |
| Chemical Properties | white to off-white powder | | Uses | It is used as pharmaceutical intermediate. Reactions of aldehydes with triphenylphosphine and sodium chlorodifluoroacetate yield 1,1-difluoro olefins. It is a general reaction and a one step synthesis. | | Application | Sodium chlorodifluoroacetate is used for generation of difluorocarbene and the synthesis of difluorocyclopropanes and difluoroalkenes. | | Preparation | Sodium chlorodifluoroacetate is prepared by careful neutralization of 130.5 g (1.0 mol) of chlorodifluoroacetic acid in 300
mL of Et2O with 53 g (0.5 mol) of anhydrous Na2CO3. The Et2O and water are removed under reduced pressure. The salt is
then dried in a vacuum desiccator over P2O5. [1] | | storage | Sodium chlorodifluoroacetate is an irritant and is hygroscopic. | | References | 1. Herkes, F. E.; Burton, D. J. OSC 1973, 5, 949 |
| | Sodium chlorodifluoroacetate Preparation Products And Raw materials |
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