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| | t-Boc-aminooxy-PEG5-propargyl Basic information |
| Product Name: | t-Boc-aminooxy-PEG5-propargyl | | Synonyms: | t-Boc-aminooxy-PEG5-propargyl;Boc-aminooxy-PEG5-propargyl;3,6,9,12,15,18-Hexaoxa-2-azaheneicos-20-ynoic acid, 1,1-dimethylethyl ester;Boc-NH-O-PEG5-Propargyl | | CAS: | 2086688-98-2 | | MF: | C18H33NO8 | | MW: | 391.46 | | EINECS: | | | Product Categories: | | | Mol File: | 2086688-98-2.mol |  |
| | t-Boc-aminooxy-PEG5-propargyl Chemical Properties |
| density | 1.087±0.06 g/cm3(Predicted) |
| | t-Boc-aminooxy-PEG5-propargyl Usage And Synthesis |
| Description | t-Boc-aminooxy-PEG5-propargyl is a click crosslinker. Propargyl group is reactive with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. T-Boc-aminooxy can be converted to free aminooxy under mild acidic conditions and then can react with an aldehyde or ketone. The hydrophilic PEG spacer increases solubility in aqueous media. | | Uses | Boc-aminooxy-PEG5-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Boc-aminooxy-PEG5-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | PEGs | | References | [1] Zhao B, et al. Protein Engineering in the Ubiquitin System: Tools for Discovery and Beyond. Pharmacol Rev. 2020 Apr;72(2):380-413. DOI:10.1124/pr.118.015651 |
| | t-Boc-aminooxy-PEG5-propargyl Preparation Products And Raw materials |
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