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| | m-PEG3-acid chloride Basic information |
| Product Name: | m-PEG3-acid chloride | | Synonyms: | m-PEG3-acid chloride;m-PEG3-Propanoyl chloride;Propanoyl chloride, 3-[2-(2-methoxyethoxy)ethoxy]- | | CAS: | 66722-87-0 | | MF: | C8H15ClO4 | | MW: | 210.66 | | EINECS: | | | Product Categories: | | | Mol File: | 66722-87-0.mol |  |
| | m-PEG3-acid chloride Chemical Properties |
| | m-PEG3-acid chloride Usage And Synthesis |
| Description | m-PEG3-acid chloride is a PEG linker containing a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. | | Uses | m-PEG3-Propanoyl chloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | m-PEG3-acid chloride Preparation Products And Raw materials |
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