4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID

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Products Intro:	Product Name:4H-Thieno[3,2-b]pyrrole-5-carboxylic acid CAS:39793-31-2 Purity:97+% Package:1g;10g;100g;;1kg Remarks:Z-22526

4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID manufacturers

4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID Basic information

Product Name:	4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID
Synonyms:	4H-thieno[3,2-b]pyrrole-5-carboxylic acid(SALTDATA: FREE);Thieno[2,3-b]pyrrole-5-carboxylic acid;4H-thieno[2,3-d]pyrrole-5-carboxylic acid;D-Amino Acid Oxidase Inhibitor;4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID;AKOS BB-9991;CHEMBRDG-BB 4012315;D-Amino Acid Oxidase Inhibitor - CAS 39793-31-2 - Calbiochem
CAS:	39793-31-2
MF:	C7H5NO2S
MW:	167.19
EINECS:
Product Categories:
Mol File:	39793-31-2.mol

4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID Chemical Properties

Melting point	180 °C
Boiling point	437.4±25.0 °C(Predicted)
density	1.609
storage temp.	Sealed in dry,2-8°C
solubility	DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml; Ethanol: 2 mg/ml
form	Beige solid
pka	4.36±0.30(Predicted)
color	Light brown to gray
InChI	InChI=1S/C7H5NO2S/c9-7(10)5-3-6-4(8-5)1-2-11-6/h1-3,8H,(H,9,10)
InChIKey	PMHDSACGRKBACK-UHFFFAOYSA-N
SMILES	N1C(C(O)=O)=CC2SC=CC1=2

Safety Information

MSDS Information

4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID Usage And Synthesis

Uses	DAO-IN-2 is a novel D-amino acid oxidase (DAO) inhibitor. DAO-IN-2 demonstrates moderate potency for DAO in vitro and ex vivo[1].
Synthesis Reference(s)	Journal of the American Chemical Society, 79, p. 2556, 1957 DOI: 10.1021/ja01567a053
General Description	A cell-permeable thienopyrrole compound that potently inhibits the cellular activity of transfected D-amino acid oxidase (DAO/DAAO/DAMOX/OXDA) in CHO cells (IC₅₀ against human and rat DAO = 145 and 114 nM, respectively), while exhibiting no activity towards D-aspartate oxidase (DDO; IC₅₀ >5 μM), P450 enzymes CYP3A4/2D6/3C9 (IC₅₀ >10 μM), and a panel of over 150 other enzymes, receptors, and ion channels. Although in vivo treatment of Compound 8 (200 mg/kg, i.p.) is shown to effectively inhibit DAO activity in rat brain and kidney (by 96% and 80%, respectively), the resulting D-serine concentration increase in the periphery and central nervous system appears to be far from sufficient to produce adequate antipsychotic and cognitive enhancing effects.
References	[1] Tim Sparey, et, al. The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors. Bioorg Med Chem Lett. 2008,18, 11. DOI:10.1016/j.bmcl.2008.04.020

4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID Preparation Products And Raw materials

Tag:4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID(39793-31-2) Related Product Information

Ethyl thiazole-5-carboxylate 4-Thiazolecarboxylic acid Thiazole-5-carboxylic acid THIAZOLE-4-CARBOXAMIDE 4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID Ethyl 4H-thieno[2,3-d]pyrrole-5-carboxylate 3-BROMO-4(H)-THIENO[3,2-B]PYRROLE-5-CARBOXYLICACID 6H-THIENO[2,3-B]PYRROLE-5-CARBOXYLIC ACID ETHYL ESTER METHYL 2-METHYL-4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLATE ETHYL 2-CHLORO-4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLATE ETHYL 3-METHYL-4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLATE 4-METHYL-4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID,4-Methyl-4H-thieno[3,2-b]pyrrole-5-carboxylic acid 97% 4-CARBOXYMETHYL-4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID ETHYL 3-CHLORO-4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLATE METHYL 4H-THIENO[3,2-B!PYRROLE-5-CARBOXYLATE, 97+% 2-METHYL-4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLIC ACID METHYL 4-METHYL-4H-THIENO[3,2-B]PYRROLE-5-CARBOXYLATE 6H-THIENO[2,3-B]PYRROLE-5-CARBOXYLIC ACID

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