ZD 7155盐酸盐
| 中文名称 | ZD 7155盐酸盐 |
|---|---|
| 中文同义词 | ZD 7155盐酸盐;1-((2'-(2H-四氮唑-5-基)-[1,1'-联苯]-4-基)甲基)-5,7-二乙基-3,4-二氢-1,6-二氮杂萘-2(1H)-酮盐酸盐;化合物 T13390;ZD 7155盐酸盐,10 MM DMSO 溶液;化合物:ZD 7155 hydrochloride CAS:146709-78-6;化合物：ZD 7155 hydrochloride CAS:146709-78-6 |
| 英文名称 | 5,7-Diethyl-3,4-dihydro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one hydrochloride |
| 英文同义词 | ZD 7155 HYDROCHLORIDE;5,7-Diethyl-3,4-dihydro-1-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-onehydrochloride;ZD7155HCl;ZD7155 hydrochloride >=97% (HPLC);1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-5,7-diethyl-3,4-dihydro-1,6-naphthyridin-2(1H)-one hydrochloride;ZD 7155 hydrochloride, 10 mM in DMSO;1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-5,7-diethyl-3,4-dihydro-1,6-naphthyridin-2(1H)-one hydrochloride;5,7-Diethyl-3,4-dihydro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one hydrochloride |
| CAS号 | 146709-78-6 |
| 分子式 | C26H26N6O.ClH |
| 分子量 | 474.99 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 146709-78-6.mol |
| 结构式 |  |
ZD 7155盐酸盐 性质
| 储存条件 | Inert atmosphere,2-8°C |
|---|---|
| 溶解度 | 二甲基亚砜：10mM |
| 形态 | 粉末 |
| 颜色 | 白色至黄色 |
| 水溶解性 | Soluble to 10 mM in water with gentle warming |
| InChIKey | NAGGAAHTUXEGFG-UHFFFAOYSA-N |
| SMILES | CCC1=C(C2=CC(CC)=N1)CCC(N2CC3=CC=C(C=C3)C4=C(C=CC=C4)C5=NN=NN5)=O.Cl |
Target: AT1 receptor
In conscious SD rats, ZD 7155 and losartan behave as competitive antagonists and the pressor response curve to angiotensin II is shifted to the right. Experiments in conscious SD rats also show that ZD 7155 is approximately ten times as potent as losartan in suppressing the angiotensin II-induced pressor response (240 ng/kg; 10 min infusion). In addition, experiments with conscious rats demonstrate that ZD 7155 could suppress the angiotensin II-induced pressor response for approximately 24 h when ZD 7155 is administered intravenously in a 1.082 μmol/kg bolus dose and angiotensin II is given at 240 ng/kg (in a 10-min infusion). Experiments in conscious SHRs using ZD 7155 (1.082 mumol/kg) and losartan (6.495 mumol/kg) as intravenous boluses indicate that both ZD 7155 and the reference compound losartan exhibit a significant antihypertensive effect.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-102093 | ZD 7155盐酸盐 ZD 7155(hydrochloride) | 146709-78-6 | 5mg | 1200元 |
| 2026/06/05 | HY-102093 | ZD 7155盐酸盐 ZD 7155(hydrochloride) | 146709-78-6 | 10mM * 1mLin DMSO | 1254元 |