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| | Heptaminol hydrochloride Basic information |
| Product Name: | Heptaminol hydrochloride | | Synonyms: | (5-Hydroxy-1,5-diMethylhexyl)aMine Hydrochloride;2-AMino-6-hydroxy-6-Methylheptane Hydrochloride;6-Hydroxy-6-Methyl-2-aMinoheptane Hydrochloride;6-Hydroxy-6-Methyl-2-heptaMine Hydrochloride;6-Hydroxy-6-Methyl-2-heptylaMine Hydrochloride;Corasore Hydrochloride;2-methyl-6-amino-2-heptanolhydrochloride;6-amino-2-methyl-2-heptanohydrochloride | | CAS: | 543-15-7 | | MF: | C8H20ClNO | | MW: | 181.7 | | EINECS: | 208-837-5 | | Product Categories: | Aliphatics;Amines;Intermediates & Fine Chemicals;Pharmaceuticals;API | | Mol File: | 543-15-7.mol |  |
| | Heptaminol hydrochloride Chemical Properties |
| Melting point | 165-167 °C(lit.) | | storage temp. | Store at -20°C | | solubility | Freely soluble in water, soluble in alcohol, practically insoluble in methylene chloride. | | form | Solid | | color | White to off-white | | Sensitive | Hygroscopic | | Merck | 14,4657 | | BRN | 3673011 | | Major Application | pharmaceutical (small molecule) | | InChI | 1S/C8H19NO.ClH/c1-7(9)5-4-6-8(2,3)10;/h7,10H,4-6,9H2,1-3H3;1H | | InChIKey | JZNBMCOSOXIZJB-UHFFFAOYSA-N | | SMILES | Cl.CC(N)CCCC(C)(C)O | | CAS DataBase Reference | 543-15-7(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 22-24/25 | | WGK Germany | 3 | | RTECS | MJ3240000 | | Storage Class | 11 - Combustible Solids | | Toxicity | LD50 intraperitoneal in mouse: 900mg/kg |
| | Heptaminol hydrochloride Usage And Synthesis |
| Chemical Properties | White or almost white, crystalline powder | | Uses | Heptaminol Hydrochloride is used in the preparation of drugs for treating cardiovascular and cerebrovascular diseases. | | Uses | Antihypotensive | | in vivo | Heptaminol hydrochloride (12 μL; 50% water/acetone) stimulates NO synthesis from constitutive NOS and attenuates TPA-induced depletion of NK cells at the edge of the mouse ear. Heptaminol hydrochloride exerts anti-proliferative and anti-inflammatory effects on TPA, suggesting important anti-tumor function[2].
| Animal Model: | Acute TPA-induced inflammatory ear skin changes in Balb/c mouse (5-7 wk)[2] | | Dosage: | 2.5 nmol Heptaminol in 12 μL | | Administration: | Topical treatment for single dose; Heptaminol was dissolved in 50% water/acetone; 30 min before 0.4 nmol TPA (in 12 μL acetone) treatment. | | Result: | Stimulated NO production and directly inhibits tumors caused by TPA promoting inflammation.
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| | Heptaminol hydrochloride Preparation Products And Raw materials |
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