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- 2-AMINO CYCLOPENTANOL
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- $2.00
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2020-01-08
- CAS:89381-13-5
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 100g , 1kg, 5kg , 50kg
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| | 2-Amino cyclopentanol Basic information | | Uses |
| Product Name: | 2-Amino cyclopentanol | | Synonyms: | Cyclopentanol,2-amino-(6CI,7CI,9CI);Cyclopentanol, 2-aMino-;2-AMinocyclopentanol, 95+%;trans-2-Amino-cyclopentanol;1-AMino-2-hydroxycyclopentane;2-HydroxycyclopentylaMine;2-aminocyclopentan-1-ol;2-AminocycL | | CAS: | 89381-13-5 | | MF: | C5H11NO | | MW: | 101.15 | | EINECS: | | | Product Categories: | VARIOUSAMINE;pharmacetical | | Mol File: | 89381-13-5.mol |  |
| | 2-Amino cyclopentanol Chemical Properties |
| Boiling point | 114-115℃ (13 Torr) | | density | 1.0617 g/cm3(Temp: 15 °C) | | refractive index | 1.4965 (589.3 nm 15℃) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 14.93±0.40(Predicted) | | Appearance | Colorless to light yellow Liquid | | CAS DataBase Reference | 89381-13-5(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 22-37/38-41 | | Safety Statements | 26-39 | | RIDADR | UN3082 | | HazardClass | 9 |
| | 2-Amino cyclopentanol Usage And Synthesis |
| Uses | 2-Aminocyclopentanol can be used as a pharmaceutical synthesis intermediate. It can be prepared from cyclopentane oxide as a reaction raw material. It can be used to prepare 5-methyl-2-(pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one compounds. It can also be used to prepare drugs for treating diseases related to cyclin-dependent kinase signaling pathways. | | Synthesis | General procedure for the synthesis of (1S,2S)-2-aminocyclopentanol from the compound (CAS:672310-36-0): 0.900 g (3.82 mmol) of (S,S)-2-benzyloxycarbonylaminocyclopentanol and 0.36 g of 5% palladium-carbon catalyst were added to the reaction system in a 50 mL autoclave. Under nitrogen protection, 4.5 mL of degassed methanol was added to the reaction system. The reaction mixture was stirred at 50 °C for 3 hours under hydrogen pressure of 2 MPa. Upon completion of the reaction, the palladium-carbon catalyst was removed by diatomaceous earth filtration, and the filtrate was concentrated by rotary evaporator to give 0.59 g of crude product. The product was determined to have an enantiomeric excess (ee) percentage of more than 99%. The 1H-NMR (200 MHz, CDCl3) data of the product were as follows: δ 1.2-1.3 (m, 1H), 1.5 (m, 1H), 1.6-1.7 (m, 2H), 1.9-2.0 (m, 2H), 2.3-2.5 (br, 3H), 3.0 (m, 1H), 3.7 (m, 1H). | | References | [1] Patent: EP1398310, 2004, A1. Location in patent: Page 16-17 |
| | 2-Amino cyclopentanol Preparation Products And Raw materials |
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