1-(6-Chloro-pyridazino-3-yl)piperidine manufacturers
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| | 1-(6-Chloro-pyridazino-3-yl)piperidine Basic information |
| Product Name: | 1-(6-Chloro-pyridazino-3-yl)piperidine | | Synonyms: | 3-CHLORO-6-PIPERIDIN-1-YL-PYRIDAZINE;3-CHLORO-6-(1-PIPERIDINYL)PYRIDAZINE;1-(6-CHLORO-PYRIDAZINO-3-YL)PIPERIDINE;3-Chloro-6-piperidinopyridazine;3-CHLORO-6-(1-PIPERIDINYL)PYRIDAZINE;3-chloro-6-(1-piperidyl)pyridazine;Pyridazine, 3-chloro-6-(1-piperidinyl)-;1-(6-Chloro-pyridazino-3-yl)piperidine ISO 9001：2015 REACH | | CAS: | 1722-11-8 | | MF: | C9H12ClN3 | | MW: | 197.66 | | EINECS: | 200-001-2 | | Product Categories: | | | Mol File: | 1722-11-8.mol |  |
| | 1-(6-Chloro-pyridazino-3-yl)piperidine Chemical Properties |
| Melting point | 80~82℃ | | Boiling point | 388.6±27.0 °C(Predicted) | | density | 1.234±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 3.62±0.10(Predicted) |
| Hazard Codes | Xi | | HazardClass | IRRITANT | | HS Code | 2933998090 |
| | 1-(6-Chloro-pyridazino-3-yl)piperidine Usage And Synthesis |
| Synthesis | GENERAL METHOD: Anhydrous ethanol (5 mL) and 3,6-dichloropyridazine (3.36 mmol) were added to a 50 mL round-bottomed flask, followed by triethylamine (5.03 mmol) and hexahydropyridine (5.03 mmol). The reaction mixture was stirred under ethanol reflux conditions for 3,6-dichloropyridazine and 3,6-dichloropyrazine and at room temperature for 3,6-dichloropyrimidine. The reaction process was monitored by gas chromatography (GC). When the starting material 3,6-dichloropyridazine was completely consumed, the reaction mixture was poured into saturated ammonium chloride solution (20 mL) and extracted with dichloromethane (3 x 20 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was ground with petroleum ether and filtered through a Büchner funnel to give pure 1-(6-chloropyridazin-3-yl)piperidine. | | References | [1] Tetrahedron, 2015, vol. 71, # 29, p. 4859 - 4867
[2] Journal of Organic Chemistry, 2013, vol. 78, # 2, p. 370 - 379
[3] European Journal of Medicinal Chemistry, 2015, vol. 95, p. 277 - 301
[4] Yakugaku Zasshi, 1954, vol. 74, p. 1195,1197
[5] Chem.Abstr., 1955, p. 14768 |
| | 1-(6-Chloro-pyridazino-3-yl)piperidine Preparation Products And Raw materials |
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